It was concluded that the combination of some biomarkers (additional chromosomes 11, high PCNA and DNA indices) may allow identification of more aggressive colorectal adenomas with increased ability to undergo malignant transformation.
The expression of BGP, oncogene products and proliferating cell nuclear antigen in the gastric and colorectal carcinomas, their premalignant lesions, and the normal mucosa were examined using 136 gastric and 96 colorectal surgically resected specimens, and 55 endoscopically resected colorectal adenomas.