|
POU5F1P4
|
0.100 |
Biomarker
|
group |
BEFREE |
siRNA-mediated knockdown of ID1 disrupts Nanog- and Oct-4-mediated cancer stem cell-likeness and resistance to chemotherapy in gastric cancer cells.
|
28529558 |
2017 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The CS12 gastric cell line showed cancer cell phenotypes, i.e. the ability of anchorage-independent growth high frequency (44%) and to the expression of Oct-4, a transcription factor expressed in embryonic stem cells and many types of cancer cells, and tumor development in immune deficient mice.
|
19424076 |
2009 |
|
POU5F1P4
|
0.100 |
Biomarker
|
group |
BEFREE |
The gene and protein expression levels of pluripotent stem cell markers (Tra-1-60, Oct4, Nanog) and cancer stem cell markers (CD133, CD44) were up-regulated in transduced Rbc51 cells compared to control cells.
|
27856246 |
2017 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
group |
BEFREE |
OCT4-pg1, OCT4-pg3 and OCT4-pg4 but excluding the OCT4 gene, were found to be expressed in two types of human solid tumours, glioma and breast carcinoma, from which cancer stem cells had earlier been isolated.
|
21341266 |
2011 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Both Oct3/4 and Sox2 were variably expressed in the cancer cell lines, but were either negative or very weakly expressed in the normal cell line.
|
19414369 |
2009 |
|
POU5F1P4
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, we analyzed the expression and clinical significance of epithelial-to-mesenchymal transition (EMT) markers (E-cadherin and N-cadherin) and cancer stem cell (CSC) markers (Nanog, Oct-4, and Sox-2) in CRC tissues.
|
29081665 |
2017 |
|
POU5F1P4
|
0.100 |
Biomarker
|
group |
BEFREE |
Stemness state in cancer stem cells (CSCs) was evaluated by the changes of CSC biomarkers including Oct-4 and ABCG2.
|
26289851 |
2016 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
group |
BEFREE |
NFATc3 plays an oncogenic role in oral/oropharyngeal squamous cell carcinomas by promoting cancer stemness via expression of OCT4.
|
31040921 |
2019 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
group |
BEFREE |
TAZ knockdown results in inhibition of cancer cell proliferation through decreases in expression of stem cell markers (OCT4, Nanog, and SOX2).
|
25495189 |
2015 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Differential expression of Oct4 variants and pseudogenes in normal urothelium and urothelial cancer.
|
23933063 |
2013 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The OCT4 transcription factor is a crucial stem cells marker and it has been related to the cancer stem cells concept.
|
25355160 |
2015 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In AOE cells, luciferase reporter assays further revealed that miR-145 directly targets the 3' UTR regions of Oct4 and Sox2 and overexpression of Sox2/Oct4 effectively reversed miR-145-regulated cancer stemness-associated phenomenas.
|
27557511 |
2016 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
group |
BEFREE |
CLIC4 expression is lowest in MKN45 cells，which have the highest tumorigenic potential and express the highest levels of cancer stem cell markers CD44 and OCT4, compared to N87 and AGS cells.
|
31560739 |
2019 |
|
POU5F1P4
|
0.100 |
Biomarker
|
group |
BEFREE |
The present data shows that Oct4 enhances cancer stem cell properties and increases invasion ability in the Huh7 cell line.
|
28454439 |
2017 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Compared with differentiated cells, constitutive Noxa levels were significantly higher in Oct-4-positive cell lines and cancer patient samples.
|
23302226 |
2013 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Among astrocytomas, mRNA expression of OCT4, MYC and (less robust) KLF4 increased with malignancy, while in recurrent glioblastomas MYC expression slightly decreased.
|
27600094 |
2016 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Real-time PCR was used to determine the expression levels of several reported cancer stem cell (CSC) markers, including CD44, CD133, ALDH1 and OCT4, in three OSCC cell lines.
|
28215944 |
2017 |
|
POU5F1P4
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumorspheres derived from epidermal growth factor receptor (EGFR)-mutant HCC827 and EGFR wild-type A549 cells expressing higher cancer stemness markers (CD133, Oct4, and Nanog) were used as cancer stemness models.
|
28787001 |
2017 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In conclusion, we demonstrated that Oct-4 expression plays a crucial role in maintaining the self-renewing, cancer stem-like, and chemoradioresistant properties of LC-CD133(+).
|
18612434 |
2008 |
|
POU5F1P4
|
0.100 |
Biomarker
|
group |
BEFREE |
Octamer-binding transcription factor 4 (Oct4) protein, encoded by the POU class 5 homeobox 1 gene, is important in maintaining self-renewal of pluripotent stem cells, and is closely associated with cancer.
|
28123573 |
2017 |
|
POU5F1P4
|
0.100 |
Biomarker
|
group |
BEFREE |
Treatment of tumor-bearing mice with genotoxic chemotherapy not only prolonged survival and reduced tumor size but also selectively eliminated the OCT4-positive cancer stem cells.
|
29141221 |
2017 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of OCT4 in cancer tissues and cell lines appeared to be highly controversial since it was believed that OCT4 is exclusively expressed in embryonic stem/embryonic carcinoma cells.
|
29022482 |
2017 |
|
POU5F1P4
|
0.100 |
Biomarker
|
group |
BEFREE |
We further demonstrated that inactivation of p38 is a potential mechanism contributing to acquisition and maintenance of cancer stem cell properties in non-small cell lung cancer (NSCLC) cells. p38, in particular the p38γ and p38δ isoforms, suppresses the cancer stem cell properties and tumor initiating ability of NSCLC cells by promoting the ubiquitylation and degradation of stemness proteins such as SOX2, Oct4, Nanog, Klf4 and c-Myc, through MK2-mediated phosphorylation of Hsp27 that is an essential component of the proteasomal degradation machinery.
|
28460458 |
2017 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Hypoxia also enhanced the expression of cancer stem cell (CSC) transcription factors (NANOG, Oct4, SOX2), CD133 and EMT markers (N-cadherin, Vimentin), thereby supporting invasion.
|
31634481 |
2019 |
|
POU5F1P4
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The high expression of cancer stem cell transcription factors (Oct4, Sox2 and Nanog) is a valuable prognostic factor, suggesting a higher risk of tumor recurrence and metastasis.
|
29907293 |
2018 |