Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker group BEFREE Our research indicates that the UCHL1-HIF-1 pathway plays a crucial role in tumor malignancy, making it a promising therapeutic target for cancer chemotherapy. 31729096 2020
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker group BEFREE HIF-1 is regarded as a promising target for the drugs used in cancer chemotherapy, and creating readily accessible templates for the development of synthetic drug candidates that could inhibit HIF-1 transcriptional activity is an important pursuit. 31740202 2020
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker group BEFREE Hence, targeting HIF-1 pathway is regarded as a promising strategy to treat cancer. 31724069 2020
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker group BEFREE Taken together, we illustrate multiple SETD2-regulated cellular pathways that suppress cancer development and uncover mechanisms underlying aberrant cell cycle regulation in SETD2-depleted cells. 30487242 2019
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 AlteredExpression group BEFREE Ascorbate can moderate HIF-1 activity in vitro and is associated with HIF pathway activation in a number of cancer types, but whether tissue ascorbate levels influence the HIF pathway in breast cancer is unknown. 30943919 2019
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker group BEFREE Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that plays essential roles in human diseases including cancer. 31392931 2019
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 AlteredExpression group BEFREE Clinically, hypoxia and the hypoxia inducible transcription factors HIF-1 and HIF-2 are associated with cancer stem cells, metastasis and drug resistance in multiple tumor types. 31201715 2019
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker group BEFREE Verucopeptin is an inhibitor of hypoxia-inducible factor 1 (HIF-1), which is a promising target for cancer chemotherapy. 31531455 2019
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker group BEFREE Among iron-dependent dioxygenases, important targets for stimulation by vitamin C in cancer include prolyl hydroxylases targeting the hypoxia-inducible factors HIF-1/HIF-2 and histone and DNA demethylases. 30695991 2019
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 AlteredExpression group BEFREE The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapy. 31070059 2019
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker group BEFREE Hypoxia-inducible factors 1 and 2 (HIF-1 and HIF-2) are nuclear proteins that transactivate many genes essential for cancer survival and metastasis under hypoxic conditions. 30837551 2019
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker group BEFREE In order to discover novel hypoxia-inducible factor 1 (HIF-1) inhibitors for the cancer metastasis treatment, 68 new aryl carboxamide compounds were synthesized and evaluated for their inhibitory effect by dual luciferase-reporter assay. 31556611 2019
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker group BEFREE HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance. 30634433 2019
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker group BEFREE Tenascin-C is involved in promotion of cancer stemness via the Akt/HIF1ɑ axis in esophageal squamous cell carcinoma. 30904401 2019
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker group BEFREE In this review, recent progress of small molecular inhibitors of protein-protein interactions targeting HIF-1 is summarized, the mechanism of functions of these compounds and their potential usage as anti-cancer agents have also been discussed. 30819620 2019
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker group BEFREE The cellular metabolic reprogramming in cancer is regulated by several oncogenic proteins and tumor suppressors such as hypoxia-inducible factor (HIF-1), Myc, p53, and PI3K/Akt/mTOR pathway. 31678210 2019
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker group BEFREE Therefore, HIF-1 is a viable target for cancer therapy. 31485300 2019
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 AlteredExpression group BEFREE HIF-1α-derived cell-penetrating peptides inhibit ERK-dependent activation of HIF-1 and trigger apoptosis of cancer cells under hypoxia. 30535970 2019
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker group BEFREE The objective of this review is to provide comprehensive insight on the effects of Chinese herbal medicines on angiogenesis by regulating HIF-1 pathways in both cancer and ischemic stroke. 31297056 2019
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 AlteredExpression group BEFREE The hypoxia-inducible transcription factor HIF-1 is appreciated as a promising target for cancer therapy. 31043706 2019
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker group BEFREE Due to its key role in promoting tumor survival and progression under hypoxia, HIF-1 has become a promising target of cancer therapy. 31083403 2019
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker group BEFREE Thus, although studies of SETD2-dependent processes in cancer have contributed to a better understanding of the SETD2⁻H3K36me3 axis, many open questions remain regarding its specific role in leukemia. 30818762 2019
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 AlteredExpression group BEFREE These surprising results delineate a mechanism by which a transcription factor switches cells from ERK to p38 signaling in response to chemotherapy and suggest that therapeutic targeting of HIF1 or the p38 pathway in combination with chemotherapy will block BCSC enrichment and improve outcome in TNBC.<b>Significance:</b> These findings provide a molecular mechanism that may account for the increased relapse rate of women with TNBC who are treated with cytotoxic chemotherapy and suggest that combining chemotherapy with an inhibitor of HIF1 or p38 activity may increase patient survival.<i>Cancer Res; 78(15); 4191-202.©2018 AACR</i>. 29880481 2018
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 AlteredExpression group BEFREE Warburg effect is characterized by the upregulation of HIF-1 and c-Myc regulated LDH-A, even aerobically owing to hypoxic environment and alterations in oncogenes or tumor suppressor genes in cancer. 29866021 2018
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 Biomarker group BEFREE These results suggest that P4HA1 promotes chemoresistance by modulating HIF-1-dependent cancer cell stemness. 30367042 2018