| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | group | BEFREE | Neither lifelong genetic inhibition of ATP citrate lyase nor lifelong genetic inhibition of HMGCR was associated with an increased risk of cancer. | 30865797 | 2019 | ||||
|
0.080 | Biomarker | group | BEFREE | Statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, are a well-known class of drug with beneficial therapeutic effects in cardiovascular disease and lipid disorders and have potential use against cancer. | 30203471 | 2019 | ||||
|
0.080 | Biomarker | group | BEFREE | Myopathy due to HMGCR antibodies in adult mimicking muscular dystrophy associated with cancer and statin exposure - narrative review of the literature - case report. | 29785116 | 2018 | ||||
|
0.080 | GeneticVariation | group | BEFREE | Blood lipid genetic scores, the HMGCR gene and cancer risk: a Mendelian randomization study. | 29165714 | 2018 | ||||
|
0.080 | Biomarker | group | BEFREE | Clinical application of statins is marred by dose-limiting toxicities and mixed outcomes on cancer risk, survival and mortality, partially resulting from the statin-mediated compensatory upregulation of HMGCR and indiscriminate inhibition of HMGCR in normal and tumor cells. | 30662405 | 2018 | ||||
|
0.080 | Biomarker | group | BEFREE | Studies have shown that high breast tumour expression of the statin target (3-hydroxy-3-methylglutaryl coenzyme-A reductase) is associated with lymph-node negative cancer. | 28720842 | 2017 | ||||
|
0.080 | Biomarker | group | BEFREE | All had aAbs to 3-hydroxy-3-methylglutaryl coenzyme A reductase, and none had overlap aAbs, aAbs to signal recognition particle, or cancer. | 28099331 | 2017 | ||||
|
0.080 | GeneticVariation | group | BEFREE | A single nucleotide polymorphism in the 3-hydroxy-3-methylglutaryl-coenzyme A reductase gene ( HMGCR) influences the serum triacylglycerol relationship with dietary fat and fibre in the European Prospective Investigation into Cancer and Nutrition in Norfolk (EPIC-Norfolk) study. | 20540816 | 2010 |