|
MIR486-1
|
0.100 |
Biomarker
|
disease |
BEFREE |
It can be concluded that miR-486-5p may act as a tumor suppressor contributing to the progression of NSCLC, and miR-486-5p would be a diagnostic and prognostic biomarker and a potential therapeutic target for lung cancer.
|
31402930 |
2019 |
|
MIR486-1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
After identifying DE miRNAs for each of 991 lung cancer samples from The Cancer Genome Atlas with RankMiRNA, we found that hsa-mir-210 was upregulated, while hsa-mir-490 and hsa-mir-486 were downregulated in > 90% of the 991 lung cancer samples.
|
28334118 |
2018 |
|
MIR486-1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Propofol inhibits lung cancer cell viability and induces cell apoptosis by upregulating microRNA-486 expression.
|
28076456 |
2017 |
|
MIR486-1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, a decreased expression of miR-486 and an increased expression of BCAP were found in tumor tissues of lung cancer patients.
|
28924214 |
2017 |
|
MIR486-1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings support the conclusion that mir-486-5p is positively regulated by mir-660-5p in lung cancer cell lines, through the mir-660-MDM2-p53 pathway, making mir-660-5p even more interesting for its potential successful use in lung cancer therapy.
|
28124991 |
2017 |
|
MIR486-1
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, miR-181b-5p and miR-486-5p were rarely reported in lung cancer related studies.
|
27291819 |
2016 |
|
MIR486-1
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we found that miR-486-5p was significantly downregulated in non-small cell lung cancer (NSCLC) tissues and cell lines, suggesting that miR-486-5p might function as a tumor suppressor in lung cancer.
|
27049724 |
2016 |
|
MIR486-1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer.
|
23474761 |
2014 |
|
MIR486-1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pim-1 kinase is a target of miR-486-5p and eukaryotic translation initiation factor 4E, and plays a critical role in lung cancer.
|
25342548 |
2014 |
|
MIR486-1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings support the role for miR-486 loss in lung cancer and suggest a potential biological link to p53.
|
23980150 |
2013 |
|
MIR486-1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This method exhibits ultrahigh sensitivity toward lung cancer-related miR-486-5p with a detection limit of as low as 10 fM and a large dynamic range of 6 orders of magnitude, and it can even discriminate miR-486-5p from both miRNAs with high sequence homology and its precursors (pre-miRNAs).
|
24215456 |
2013 |