Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.370 GeneticVariation disease BEFREE In the Oncomine database, FBXO11 mRNA levels were lower in normal tissues than in cancer tissues, including clear cell renal cell carcinoma (ccRCC), papillary renal cell carcinoma (pRCC), hereditary ccRCC, non-hereditary ccRCC, VHL mutant ccRCC and VHL wild-type ccRCC. 31159774 2019
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.370 PosttranslationalModification disease BEFREE The molecular mechanisms involved in pRCC development and drug resistance are more diverse than in clear-cell RCC, in which inactivation of VHL occurs in the majority of tumours. 31602010 2019
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.370 AlteredExpression disease BEFREE While the inactivation of VHL gene can be found in the majority of clear cell carcinomas, different molecular mechanisms are involved into pRCC biology. 26052049 2015
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.370 Biomarker disease CTD_human NADPH oxidase NOX4 supports renal tumorigenesis by promoting the expression and nuclear accumulation of HIF2α. 24755467 2014
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.370 GeneticVariation disease BEFREE It exhibits a different molecular signature than clear-cell carcinoma and is typically not associated with mutations in the VHL (von Hippel-Lindau) tumor suppressor gene. pRCC is less responsive to modern drugs introduced in the management of kidney cancer in the past decade. 24629521 2014
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.370 Biomarker disease CTD_human Integrated molecular analysis of clear-cell renal cell carcinoma. 23797736 2013
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.370 Biomarker disease CTD_human Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. 22138691 2011
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.370 Biomarker disease CTD_human L1-CAM expression in ccRCC correlates with shorter patients survival times and confers chemoresistance in renal cell carcinoma cells. 21097529 2011
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.370 Biomarker disease CTD_human Bilateral renal-cell carcinoma associated with an acquired VHL mutation and long-term trichloroethylene exposure. 19473641 2009
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.370 Biomarker disease BEFREE VHL status was assessed in 20 cases of clear cell renal cell carcinoma and 9 cases of papillary renal cell carcinoma by DNA sequencing and by immunohistochemical staining for the hypoxia-inducible factor-alpha target gene products CA9 and GLUT-1. 18660794 2009
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.370 GeneticVariation disease BEFREE Molecular analysis revealed deletions at 3p25-26 in one translocation carcinoma, one chromophobe renal cell carcinoma, and one papillary renal cell carcinoma.There were no VHL mutations. 15316311 2004
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.370 Biomarker disease CTD_human VHL mutations in renal cell cancer: does occupational exposure to trichloroethylene make a difference? 15177666 2004
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.370 Biomarker disease CTD_human Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis. 11171960 2001
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.370 Biomarker disease CTD_human Trichloroethylene exposure and specific somatic mutations in patients with renal cell carcinoma. 10340905 1999
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.370 Biomarker disease CTD_human Renal cell carcinomas in trichloroethene (TRI) exposed persons are associated with somatic mutations in the von Hippel-Lindau (VHL) tumour suppressor gene. 9137812 1997
Entrez Id: 7428
Gene Symbol: VHL
VHL
0.370 GeneticVariation disease BEFREE The results indicate that mutation of the VHL gene is associated exclusively with the development of non-papillary renal cell carcinoma. 8758207 1996