Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE EGFR gene copy number gains and KRAS/BRAF mutations have been reported to act as positive and negative predictors, respectively, of therapeutic response to EGFR targeted therapies in colorectal adenocarcinoma, a tumour type claimed to be genetically similar to ITAC. 23055340 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE KRAS and BRAF mutation analysis in colorectal adenocarcinoma specimens with a low percentage of tumor cells. 23606169 2013
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation disease UNIPROT
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE MAPK inhibitors induce serine peptidase inhibitor Kazal type 1 (SPINK1) secretion in BRAF V600E-mutant colorectal adenocarcinoma. 29193645 2018
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation disease CLINVAR
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE Automated PCR detection of BRAF mutations in colorectal adenocarcinoma: a diagnostic test accuracy study. 26537294 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE Sanger sequencing is one of several reliable methods in use to detect KRAS and BRAF mutations to facilitate clinical patient selection for anti-epidermal growth factor receptor (EGFR) monoclonal antibody therapy in unresectable metastatic colorectal adenocarcinoma (CRC). 21029218 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE Concordance in KRAS and BRAF mutations in endoscopic biopsy samples and resection specimens of colorectal adenocarcinoma. 22446020 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE Immunohistochemistry using the BRAF V600E mutation-specific monoclonal antibody VE1 is not a useful surrogate for genotyping in colorectal adenocarcinoma. 23763264 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease UNIPROT
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE What is not known is whether UAC in its morphologic similarity to CAC could show immunohistochemical features of MSI along with KRAS- and BRAF-activating mutations. 24355196 2014
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.500 GeneticVariation disease UNIPROT
Entrez Id: 6416
Gene Symbol: MAP2K4
MAP2K4
0.500 GeneticVariation disease UNIPROT
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.420 GeneticVariation disease CLINVAR
Entrez Id: 324
Gene Symbol: APC
APC
0.410 GeneticVariation disease GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 GeneticVariation disease BEFREE Sanger sequencing is one of several reliable methods in use to detect KRAS and BRAF mutations to facilitate clinical patient selection for anti-epidermal growth factor receptor (EGFR) monoclonal antibody therapy in unresectable metastatic colorectal adenocarcinoma (CRC). 21029218 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Expression of mutant p53 and of the multidrug resistant proteins P-glycoprotein and glutathione S-transferase-pi correlated in colorectal adenocarcinoma. 20377486 2010
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 GeneticVariation disease BEFREE High frequency of KRAS mutation in early onset colorectal adenocarcinoma: implications for pathogenesis. 27346571 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 GeneticVariation disease BEFREE Immunohistochemical detection of expression of the epidermal growth factor receptor (EGFR) has been utilized to identify eligible patients with solid malignant tumors, including colorectal adenocarcinoma, for monoclonal antibody therapy (eg, cetuximab). 16648870 2006
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Prognostic significance of p53 codon 72 polymorphism differs with race in colorectal adenocarcinoma. 19339276 2009
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 GeneticVariation disease BEFREE Eligible patients were aged 20 years or older; had histologically confirmed unresectable, metastatic colorectal adenocarcinoma; were refractory or intolerant to fluoropyrimidine, irinotecan, oxaliplatin, anti-VEGF therapy, and anti-EGFR therapy (for tumours with wild-type KRAS); and had no previous treatment with regorafenib. 28760399 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE This study adhered to MOOSE guidelines.Databases were searched for studies comparing KRAS, BRAF, microsatellite instability (MSI), CpG island methylator phenotype (CIMP), p53 and p27 status between patients with mucinous and non-mucinous colorectal adenocarcinoma. 30945755 2019
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 GeneticVariation disease BEFREE KRAS mutations were found in 13 of 42 cases (31%) of colorectal adenocarcinoma and 7 of 9 cases (78%) of villous adenoma. 21665177 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Multiple sample areas in colorectal adenocarcinoma at early and advanced stages and in metastases were studied for the well-known genetic alterations: K-ras and p53 point mutations and loss of heterozygosity (LOH) on chromosomes 5q and 18q. 15731168 2005
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.400 GeneticVariation disease BEFREE What is not known is whether UAC in its morphologic similarity to CAC could show immunohistochemical features of MSI along with KRAS- and BRAF-activating mutations. 24355196 2014