Herein, we assessed the expression of LETM1 and its relationship with cancer stemness genes, cell cycle markers, PI3K/Akt/NFκB signaling pathway genes, and HIF1α in 102 paraffin-embedded CRA tissue samples using immunohistochemistry (IHC).
Also, rhapontigenin suppressed hypoxia-induced HIF-1α activation in various cancer cells, such as colorectal adenocarcinoma (SW620), breast adenocarcinoma (MCF-7), fibrosarcoma (HT-1080) and prostate carcinoma (LNCaP).
To clarify the possible involvement of the HIF-1alpha subunit and homeodomain protein CDX2 in the development and progression of colorectal cancer (CRC), we examined in vivo the immunohistochemical expression of HIF-1alpha and its topological correlation with CDX2 expression in colorectal adenocarcinoma.