Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 Biomarker disease BEFREE This study adhered to MOOSE guidelines.Databases were searched for studies comparing KRAS, BRAF, microsatellite instability (MSI), CpG island methylator phenotype (CIMP), p53 and p27 status between patients with mucinous and non-mucinous colorectal adenocarcinoma. 30945755 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE MAPK inhibitors induce serine peptidase inhibitor Kazal type 1 (SPINK1) secretion in BRAF V600E-mutant colorectal adenocarcinoma. 29193645 2018
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE Automated PCR detection of BRAF mutations in colorectal adenocarcinoma: a diagnostic test accuracy study. 26537294 2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE What is not known is whether UAC in its morphologic similarity to CAC could show immunohistochemical features of MSI along with KRAS- and BRAF-activating mutations. 24355196 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE KRAS and BRAF mutation analysis in colorectal adenocarcinoma specimens with a low percentage of tumor cells. 23606169 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE Immunohistochemistry using the BRAF V600E mutation-specific monoclonal antibody VE1 is not a useful surrogate for genotyping in colorectal adenocarcinoma. 23763264 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE EGFR gene copy number gains and KRAS/BRAF mutations have been reported to act as positive and negative predictors, respectively, of therapeutic response to EGFR targeted therapies in colorectal adenocarcinoma, a tumour type claimed to be genetically similar to ITAC. 23055340 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE Concordance in KRAS and BRAF mutations in endoscopic biopsy samples and resection specimens of colorectal adenocarcinoma. 22446020 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 Biomarker disease BEFREE Limited reports in the literature have shown that the variant of colorectal cancer demonstrated a different pattern of genetic alterations of common growth kinase-related oncogenes (K-ras, BRAF), tumour suppressor genes (p53, p16), gene methylation and cell adhesion-related genes related to the Wingless signalling pathway (E-cadherin and beta-catenin) from conventional colorectal adenocarcinoma. 20686774 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease BEFREE Sanger sequencing is one of several reliable methods in use to detect KRAS and BRAF mutations to facilitate clinical patient selection for anti-epidermal growth factor receptor (EGFR) monoclonal antibody therapy in unresectable metastatic colorectal adenocarcinoma (CRC). 21029218 2011
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation disease UNIPROT
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 CausalMutation disease CGI
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 GeneticVariation disease CLINVAR
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 CausalMutation disease CGI
Entrez Id: 472
Gene Symbol: ATM
ATM
0.600 CausalMutation disease CLINVAR
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.600 GeneticVariation disease UNIPROT
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.500 CausalMutation disease CGI
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3
0.500 GeneticVariation disease UNIPROT
Entrez Id: 6416
Gene Symbol: MAP2K4
MAP2K4
0.500 GenomicAlterations disease CGI
Entrez Id: 6416
Gene Symbol: MAP2K4
MAP2K4
0.500 CausalMutation disease CGI
Entrez Id: 6416
Gene Symbol: MAP2K4
MAP2K4
0.500 GeneticVariation disease UNIPROT
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.420 Biomarker disease BEFREE In advanced cases of colorectal adenocarcinoma (stages III and IV), there was a higher percentage of MLH1-negative results. 31116268 2019
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.420 PosttranslationalModification disease BEFREE Aberrant methylation of hMLH1 and p16INK4a in Tunisian patients with sporadic colorectal adenocarcinoma. 20815811 2011
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.420 GenomicAlterations disease CGI
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.420 GeneticVariation disease CLINVAR