| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.100 | Biomarker | disease | BEFREE | Hammerhead ribozyme-mediated cleavage of the fusion transcript NPM-ALK associated with anaplastic large-cell lymphoma. | 12644020 | 2003 | ||||
|
0.100 | GeneticVariation | disease | BEFREE | Anaplastic large-cell lymphoma is associated with a chromosomal translocation generating an oncogenic fusion protein: the nucleophosmin-anaplastic lymphoma kinase (NPM-ALK). | 14586401 | 2003 | ||||
|
0.100 | GeneticVariation | disease | BEFREE | Anaplastic large cell lymphoma of T/null-cell type (ALCL) is associated with a characteristic genetic abnormality t(2;5) that results in the NPM-ALK chimeric gene and the protein product derived thereof. | 11957137 | 2002 | ||||
|
0.100 | Biomarker | disease | BEFREE | The NPM/ALK fusion gene, formed by the t(2;5) translocation in anaplastic large-cell lymphoma, encodes a M(r) 75,000 hybrid protein that containsthe amino-terminal portion of the nucleolar phosphoprotein nucleophosmin(NPM) joined to the entire cytoplasmic portion of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK). | 11522649 | 2001 | ||||
|
0.100 | GeneticVariation | disease | BEFREE | Anaplastic large cell lymphoma with the t(2;5)(p23;q35) NPM/ALK chromosomal translocation and duplication of the short arm of the non-translocated chromosome 2 involving the full length of the ALK gene. | 11215285 | 2001 | ||||
|
0.100 | GeneticVariation | disease | BEFREE | Pathobiology of NPM-ALK and variant fusion genes in anaplastic large cell lymphoma and other lymphomas. | 10994999 | 2000 | ||||
|
0.100 | Biomarker | disease | BEFREE | Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway. | 11110708 | 2000 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | Frequent expression of the NPM-ALK chimeric fusion protein in anaplastic large-cell lymphoma, lympho-histiocytic type. | 9094977 | 1997 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | Anaplastic large cell lymphoma: a distinct molecular pathologic entity: a reappraisal with special reference to p80(NPM/ALK) expression. | 9414185 | 1997 |