Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4615
Gene Symbol: MYD88
MYD88
0.100 GeneticVariation disease BEFREE MYD88 L265P MUTATION DETECTION IN THE AQUEOUS HUMOR OF PATIENTS WITH VITREORETINAL LYMPHOMA. 30204732 2019
Entrez Id: 4615
Gene Symbol: MYD88
MYD88
0.100 GeneticVariation disease BEFREE Oncogenic MYD88 mutations in lymphoma: novel insights and therapeutic possibilities. 30203262 2018
Entrez Id: 4615
Gene Symbol: MYD88
MYD88
0.100 GeneticVariation disease BEFREE Toll-like receptors (TLRs) and interleukin 1 receptors (IL-1R) can recognize microbes or endogenous ligands and then recruit MyD88 to activate the MyD88-dependent pathway, while MyD88 mutation associated with lymphoma development and altered MyD88 signaling also involved in cancer-associated cell intrinsic and extrinsic inflammation progression and carcinogenesis. 30086464 2018
Entrez Id: 4615
Gene Symbol: MYD88
MYD88
0.100 Biomarker disease BEFREE MYD88 Inhibitor ST2825 Suppresses the Growth of Lymphoma and Leukaemia Cells. 29061802 2017
Entrez Id: 4615
Gene Symbol: MYD88
MYD88
0.100 GeneticVariation disease BEFREE The MYD88 missense mutation c.794T>C, p.Leu265Pro, is found in patients with Waldenstörm's macroglobulinemia and lymphoma. 28042684 2017
Entrez Id: 4615
Gene Symbol: MYD88
MYD88
0.100 GeneticVariation disease BEFREE Mapping the human T cell repertoire to recurrent driver mutations in MYD88 and EZH2 in lymphoma. 28811957 2017
Entrez Id: 4615
Gene Symbol: MYD88
MYD88
0.100 GeneticVariation disease BEFREE Individuals with tumors positive for MYD88 mutations also harbored the same mutations at a low frequency in peripheral blood mononuclear cells, suggesting that MYD88 mutation-positive precancerous cells originate outside of the CNS and develop into lymphoma after additional genetic hits that confer adaptation to the CNS environment. 26757737 2016
Entrez Id: 4615
Gene Symbol: MYD88
MYD88
0.100 GeneticVariation disease BEFREE Myeloid differentiation primary response 88 (MYD88) is a common adaptor protein that is responsible for signaling from several receptors; mutations in this gene may play a role in the pathogenesis of lymphoma. 25978699 2015
Entrez Id: 4615
Gene Symbol: MYD88
MYD88
0.100 GeneticVariation disease BEFREE MYD88 mutations were identified in 20 of 29 (69%) clinically, histologically, and molecularly confirmed VRL, including 6 cases of the test cohort initially diagnosed as reactive (3/6) or suspicious (3/6) for lymphoma. 25900979 2015
Entrez Id: 4615
Gene Symbol: MYD88
MYD88
0.100 GeneticVariation disease BEFREE MYD88 L265P mutation has been reported in ∼90% of Waldenström's Macroglobulinemia (WM) patients and immunoglobulin M (IgM) monoclonal gammopathies of uncertain significance (MGUS), as well as in some cases of lymphoma and chronic lymphocytic leukemia. 24992174 2015
Entrez Id: 4615
Gene Symbol: MYD88
MYD88
0.100 GeneticVariation disease BEFREE Myd-88 L265P constitutive activating mutations are present in at least some cases of the diffuse large B-cell lymphoma form of vitreoretinal lymphoma. 25768255 2015
Entrez Id: 4615
Gene Symbol: MYD88
MYD88
0.100 GeneticVariation disease BEFREE Recurrent lymphoma-associated mutations, particularly Leu265Pro (L265P), within the MyD88 Toll/interleukin-1 receptor (TIR) domain sustain lymphoma cell survival due to constitutive nuclear factor κB signaling. 25359991 2014
Entrez Id: 4615
Gene Symbol: MYD88
MYD88
0.100 Biomarker disease BEFREE This review discusses the molecular and biological mechanisms underlying MYD88 mutations in LPL/WM, the role of MYD88 mutations as molecular biomarker for the refinement of diagnosis and the improvement classification of LPL/WM, and novel targeted therapeutic strategies for LPL/WM based on the pharmacological manipulation of MYD88 signaling to which this lymphoma is addicted. 25696843 2014
Entrez Id: 4615
Gene Symbol: MYD88
MYD88
0.100 GeneticVariation disease BEFREE In order to evaluate whether the presence of the recently described MYD88 L265P mutation in patients with Waldenström's macroglobulinemia (WM) is contributory to SS-associated lymphomagenesis, a quantitative allele-specific PCR method was performed in peripheral blood derived from 90 SS patients as well as in minor salivary gland tissues derived from 12 primary SS patients with or without lymphoma. 24153350 2014
Entrez Id: 4615
Gene Symbol: MYD88
MYD88
0.100 GeneticVariation disease BEFREE Mutation of the MYD88 gene has recently been identified in activated B-cell-like diffuse cell lymphoma and enhanced Janus kinase/signal transducer and activator of transcription (JAK-STAT) and nuclear factor κB (NF-κB) signaling pathways. 23532735 2013
Entrez Id: 4615
Gene Symbol: MYD88
MYD88
0.100 GeneticVariation disease BEFREE Thus, MYD88 may be crucial for lymphoma progression, independent of MYD88 L265P mutation. 23380077 2013
Entrez Id: 4615
Gene Symbol: MYD88
MYD88
0.100 GeneticVariation disease BEFREE Oncogenically active MYD88 mutations in human lymphoma. 21179087 2011