| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.100 | AlteredExpression | disease | BEFREE | Sequential emergence of MRP- and MDR1-gene over-expression as well as MDR1-gene translocation in homoharringtonine-selected K562 human leukemia cell lines. | 8575859 | 1996 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | We have isolated, by drug selection, an anthracycline-resistant HL-60 cell line that, in comparison to parental drug sensitive cells, exhibits a multidrug resistant phenotype including diminished intracellular drug retention, cross-resistance to multiple cytotoxic drugs, increased expression of a monoclonal antibody C219-reactive 180 kDa P-glycoprotein detected by Western blot analysis as well as increased expression of MDR-1 mRNA as determined by Northern blot and solution hybridization/RNAse protection analyses. | 7702633 | 1995 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | We examined the expression of the mdr1 gene in 90 human tumor cell lines of which 79 were derived from leukemia or lymphoma samples. | 8099136 | 1993 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | In addition, MDR1 expression in CD7+ AML/ALL might be responsible for the poor response to conventional chemotherapies of these types of leukemia. | 7694687 | 1993 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | These findings suggest that MDR1 gene expression is correlated with the leucocyte differentiation stage of leukemia. | 8477061 | 1993 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | Determination of mdr1 gene expression may be useful in designing therapy for patients with leukemia. | 1859877 | 1991 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | Since mdr1 and mdr3 are frequently expressed in untreated as well as treated leukemia, such combination therapy should be considered for untreated patients as well as treated patients. | 1972761 | 1990 | ||||
|
0.100 | AlteredExpression | disease | BEFREE | Increased expression and amplification of mdr1 sequences were also found in multidrug-resistant sublines of human leukemia and ovarian carcinoma cells. | 3457471 | 1986 |