Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker disease BEFREE The modification of this translocation may lead to reducing effects of the fusion gene's damaging and the dosage compensation related to ETV6 and RUNX1 genes and subsequently reduce the effects of leukemia. 31602594 2020
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 AlteredExpression disease BEFREE Taken together, this study identifies SPIB as an important target of ETV6-RUNX1 in regulation of B-cell gene expression in t(12;21) leukemia. 30986496 2019
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 AlteredExpression disease BEFREE CRKL is tightly linked to leukemia via its binding partners BCR-ABL and TEL-ABL, upregulated in multiple types of human cancers, and induce cancer cell proliferation and invasion. 31133010 2019
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker disease BEFREE We suggest that germline aberrations resulting in monoallelic expression of <i>ETV6</i> contribute to leukemia susceptibility, whereas more severe functional deficiency of ETV6 is required for developing THC5. 31519648 2019
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 GeneticVariation disease BEFREE Care for individuals with ETV6-related thrombocytopenia and leukemia predisposition includes genetic counseling, treatment or prevention of excessive bleeding and surveillance for the development of hematologic malignancy. 31248877 2019
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 GeneticVariation disease BEFREE A 4-log-stage linearity of R2 ≥ 99.81% and a sensitivity of one leukemia associated ETV6-RUNX1 mutant DNA copy in a background of 100 000 wild-type DNA copies are achieved. 31139783 2019
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker disease BEFREE Deletions affecting the transcriptional coregulator BTG1 are frequently observed in ETV6-RUNX1-positive leukemia. 29408281 2018
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 GeneticVariation disease BEFREE The prenatal origin of the rearrangement confirms that ETV6-ABL1 is not sufficient to cause overt leukemia, even when combined with the 2 novel fusions. 29726059 2018
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 GeneticVariation disease BEFREE Additionally, the ETV6-RUNX1 fusion was found to encode putative neoepitopes in a high proportion (69.6%) of the pediatric leukemia harboring this fusion. 28854978 2017
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker disease BEFREE An activating mutation of GNB1 is associated with resistance to tyrosine kinase inhibitors in ETV6-ABL1-positive leukemia. 28650474 2017
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 GeneticVariation disease BEFREE The most frequent chromosomal changes in subgroups divided according to WHO classification independent of treatment protocol and leukemia subtype were hyperdiploidy in 36 patients (with ≥50 chromosomes in 23 patients, with 47-49 chromosomes 13 patients) followed by translocation t(12;21) with ETV6/RUNX1 fusion detected by FISH in 18 (22%) patients. 27341996 2017
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 GeneticVariation disease BEFREE As few <i>ETV6-RUNX1</i> carriers develop precursor B-cell acute lymphocytic leukemia (pB-ALL), the underlying genetic basis for development of full-blown leukemia remains to be identified, but the appearance of leukemia cases in time-space clusters keeps infection as a potential causal factor. 28630052 2017
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 GeneticVariation disease BEFREE <i>ETV6-RUNX1</i> is associated with the most common subtype of childhood leukemia. 29254279 2017
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker disease BEFREE As with ABL, translocations that fuse ARG to ETV6/TEL have been identified in patients with leukemia. 28386107 2017
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 GeneticVariation disease BEFREE Space-Time Clustering of Childhood Leukemia: Evidence of an Association with ETV6-RUNX1 (TEL-AML1) Fusion. 28129329 2017
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker disease BEFREE Mechanism of ETV6-RUNX1 Leukemia. 28299659 2017
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker disease BEFREE ETV6 in hematopoiesis and leukemia predisposition. 28637624 2017
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker disease BEFREE We show here for the first time that LPXN is a fusion partner of ETV6 and present evidence indicating that ETV6-LPXN plays a crucial role in leukemia progression through enhancing the response to G-CSF and CXCL12. 26542893 2016
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker disease BEFREE Secondary chromosomal aberrations are necessary for development of overt leukemia in t(12;21)/ETV6-RUNX1-positive acute lymphoblastic leukemia (ALL). 27215399 2016
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 GeneticVariation disease BEFREE The t(12;21) translocation generating the ETV6/RUNX1 fusion gene represents the most frequent chromosomal rearrangement in childhood leukemia. 26919255 2016
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker disease BEFREE All together, our study defined a unique lncRNA expression signature associated with ETV6/RUNX1-positive BCP-ALL and identified lnc-RTN4R-1 and lnc-NKX2-3-1 as lncRNAs that might be functionally implicated in the biology of this prevalent subtype of human leukemia. 27650541 2016
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker disease BEFREE Our data suggest that ETV6/ARG oncoprotein is a potential target in the treatment of leukemia. 25373509 2015
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker disease BEFREE Our findings highlight a novel role for ETV6 in leukemia predisposition. 26102509 2015
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 Biomarker disease BEFREE Expression differences in TEL-AML1 fusion gene in leukemia glucocorticoid-sensitive and -resistant cell lines. 26214469 2015
Entrez Id: 2120
Gene Symbol: ETV6
ETV6
0.100 AlteredExpression disease BEFREE Further investigation into the clinical and biological significance of elevated MN1 expression in TEL-AML1(positive) leukemia might provide insight into additional molecular mechanisms contributing to B-ALL and may lead to improved treatment options for patients. 26111797 2015