| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | A downregulated IFN response was also observed in patients suffering from leukemia carrying STAT5B mutations. | 30679796 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Commercially, IFN-α has been approved to treat many chronic viral diseases as well as a variety of cancers and different types of leukemia. | 30543053 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Sorafenib-related IL-15 production caused an increase in CD8<sup>+</sup>CD107a<sup>+</sup>IFN-γ<sup>+</sup> T cells with features of longevity (high levels of Bcl-2 and reduced PD-1 levels), which eradicated leukemia in secondary recipients. | 29431743 | 2018 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Furthermore, IFN gene therapy strongly enhances anti-tumor activity of adoptively transferred T cells engineered with tumor-specific TCR or CAR, overcoming suppressive signals in the leukemia TME. | 30042420 | 2018 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | The identification of IFN regulatory factor 4 gene (IRF4) translocation in 8 out of 14 cases of cutaneous anaplastic large cell lymphomas (C-ALCLs) (Leukemia, 2009; 23(3):574-80) prompted us to study IRF4 locus status in different cutaneous T-cell lymphoma (CTCL) subtypes. | 19812605 | 2010 | ||||
|
0.080 | Biomarker | disease | BEFREE | However, IFN-alpha2c was detected in 4 of 33 (12.1%) patients with leukemia. | 9085937 | 1997 | ||||
|
0.080 | Biomarker | disease | BEFREE | These results demonstrate that fibroblast-mediated human IFN-alpha gene therapy is effective in treating leukemia and may achieve a better therapeutic effect when combined with Dox. | 8683976 | 1996 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | The distal breakpoints of the deletions (in relation to the centromere) in 14 glioma and leukemia cell lines have been mapped within the 400 kb IFN gene cluster located at band 9p21. | 7523863 | 1994 |