|
IGHV3-69-1
|
0.090 |
Biomarker
|
disease |
BEFREE |
In patients with B-cell chronic lymphocytic leukemia, both flow-cytometry and RQ-PCR are equally suited for MRD assessment as long as a sensitivity of 10<sup>-4</sup> shall be achieved.MRD diagnostics targeting the IGHV gene is complex and requires extensive knowledge and experience because the junctional regions of each lymphoma have to be identified before the patient-specific RQ-PCR assays can be designed for MRD monitoring.
|
30779036 |
2019 |
|
IGHV3-69-1
|
0.090 |
Biomarker
|
disease |
BEFREE |
The heterogeneous representation of IGHV genes in HIV-NHL may be related to specific pathways of antigen stimulation, or to differences in host's immune dysregulation and lymphoma histogenesis.
|
18556404 |
2008 |
|
IGHV3-69-1
|
0.090 |
Biomarker
|
disease |
BEFREE |
In classic RT, 18/23 B-CLL cases (78%) showed clonal progression to DLBCL with identical IgVH sequences in both lymphoma components, whereas in 5 cases (22%) the DLBCL was clonally unrelated.
|
17895764 |
2007 |
|
IGHV3-69-1
|
0.090 |
Biomarker
|
disease |
BEFREE |
Clinical trials of IgHV protein vaccines against lymphoma have demonstrated induction of tumor-specific cytotoxic T lymphocyte (CTL) responses.
|
17517179 |
2007 |
|
IGHV3-69-1
|
0.090 |
Biomarker
|
disease |
BEFREE |
In three of five patients who had interpretable results, a distinct, monoclonal, VH family-specific band profile was obtained from the cerebral and systemic lymphoma.
|
15372481 |
2004 |
|
IGHV3-69-1
|
0.090 |
Biomarker
|
disease |
BEFREE |
Persisting monoclonal bands for immunoglobulin heavy chain variable region (VH) representing the lymphoma clone have been described in up to 50% of patients in CR.
|
15284253 |
2004 |
|
IGHV3-69-1
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
A subset of t(11;14) lymphoma with mantle cell features displays mutated IgVH genes and includes patients with good prognosis, nonnodal disease.
|
12609845 |
2003 |
|
IGHV3-69-1
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
To further elucidate the role of antigen selection in the evolution of gastric low-grade MALT-type lymphoma, we analyzed intraclonal variations of the immunoglobulin heavy-chain variable region (Ig VH) genes expressed in three cases of lymphoma.
|
9111510 |
1997 |
|
IGHV3-69-1
|
0.090 |
Biomarker
|
disease |
BEFREE |
With one possible exception, none of these lymphoma VH sequences appear to represent any of the VH3 genes that may be preferentially used in the fetal repertoire.
|
1909196 |
1991 |