Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 406947
Gene Symbol: MIR155
MIR155
0.010 Biomarker disease BEFREE MiR-155-5p affects Wilms' tumor cell proliferation and apoptosis via targeting CREB1. 30779069 2019
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.010 Biomarker disease BEFREE MiR-572 targeted CDH1 to promote cell metastasis in WT by suppressing EMT. 31114995 2019
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.010 AlteredExpression disease BEFREE Ginger oil elevated the CAT and SOD (antioxidant enzymes), serum testosterone and diminished the oxidative stress, up regulated the expression of Vegfa and Sycp3 and down-regulated the Wt1 expression. 30530043 2019
Entrez Id: 10409
Gene Symbol: BASP1
BASP1
0.010 AlteredExpression disease BEFREE Nuclear BASP1 participates in gene regulation converting the Wilms tumor transcription factor WT1 from an oncoprotein into a tumor suppressor. 31058089 2019
Entrez Id: 6426
Gene Symbol: SRSF1
SRSF1
0.010 Biomarker disease BEFREE In podocytes, the Wilms' tumor suppressor 1 (WT1) suppresses the Serine/arginine-rich protein-specific splicing factor kinase (SRPK1), and indirectly Serine/arginine-rich splicing factor 1 (Srsf1) activity, and alters VEGF splicing. 30641926 2019
Entrez Id: 8087
Gene Symbol: FXR1
FXR1
0.010 Biomarker disease BEFREE FXR1 was detected in all clinical WT specimens evaluated (n = 82), and as a result appeared independent of demographic, histology, or adverse event. 30894247 2019
Entrez Id: 5216
Gene Symbol: PFN1
PFN1
0.010 Biomarker disease BEFREE Our data identify profilin-1 as a potential protein marker for Wilms' tumor and demonstrate the feasibility of the above procedures for screening and identification of tumor-specific protein markers. 31550443 2019
Entrez Id: 8929
Gene Symbol: PHOX2B
PHOX2B
0.010 GeneticVariation disease BEFREE Our study suggested that PHOX2B rs28647582 T>C was weakly associated with Wilms tumor susceptibility. 31652452 2019
Entrez Id: 1620
Gene Symbol: BRINP1
BRINP1
0.010 GeneticVariation disease BEFREE This study aimed to explore: 1) DNA methylation in the promoter regions of Wilms tumor gene 1 (WT1), NK6 transcription factor related locus 1 gene (NKX6-1) and Deleted in bladder cancer 1 (DBC1) gene in cervical cancer tissues of Uygur women in Xinjiang, and 2) the correlation of gene methylation with the infection of HPV16/18 viruses. 29658966 2019
Entrez Id: 4825
Gene Symbol: NKX6-1
NKX6-1
0.010 GeneticVariation disease BEFREE This study aimed to explore: 1) DNA methylation in the promoter regions of Wilms tumor gene 1 (WT1), NK6 transcription factor related locus 1 gene (NKX6-1) and Deleted in bladder cancer 1 (DBC1) gene in cervical cancer tissues of Uygur women in Xinjiang, and 2) the correlation of gene methylation with the infection of HPV16/18 viruses. 29658966 2019
Entrez Id: 664612
Gene Symbol: MIR539
MIR539
0.010 AlteredExpression disease BEFREE Furthermore, low miR-539 expression was associated with a shorter overall survival rate in WT patients. 30530967 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.010 GeneticVariation disease BEFREE Two BRAF V600E mutation-positive WTs occurred in children. 31192863 2019
Entrez Id: 5788
Gene Symbol: PTPRC
PTPRC
0.010 Biomarker disease BEFREE In this pilot study, it was found that WTs were infiltrated by immune cells (CD45+) both before and after chemotherapy. 30981637 2019
Entrez Id: 611
Gene Symbol: OPN1SW
OPN1SW
0.010 AlteredExpression disease BEFREE The prognostic significance of Wilms' tumor gene 1 (WT1) expression at diagnosis in adults with B cell precursor acute lymphoblastic leukemia (BCP-ALL) remains poorly understood. 31493003 2019
Entrez Id: 57556
Gene Symbol: SEMA6A
SEMA6A
0.010 Biomarker disease BEFREE The present study illustrates that miR-140-5p functions as a tumor suppressor in the occurrence and development of WT via targeting <i>TGFBR1</i>, which provides theoretical foundation for serving miR-140-5p as a new diagnosis marker even a therapeutic target for WT. 30863174 2019
Entrez Id: 4087
Gene Symbol: SMAD2
SMAD2
0.010 Biomarker disease BEFREE miR-140-5p could suppress tumor proliferation and progression by targeting TGFBRI/SMAD2/3 and IGF-1R/AKT signaling pathways in Wilms' tumor. 31035970 2019
Entrez Id: 5245
Gene Symbol: PHB
PHB
0.010 AlteredExpression disease BEFREE Immunohistochemical analysis revealed that prohibitin was highly expressed in primary Wilms' tumor specimens and associated with disease stage. 31391345 2019
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.010 Biomarker disease BEFREE We prospectively evaluated the specificity and sensitivity of plasminogen-activator inhibitor-1 (PAI-1) and protein C as diagnostic markers of VOD in WT patients. 30865371 2019
Entrez Id: 3791
Gene Symbol: KDR
KDR
0.010 Biomarker disease BEFREE Here, we report a case of Wilms tumor in a 24-year-old woman who was effectively treated with apatinib, a small-molecule inhibitor of vascular endothelial growth factor receptor-2. 30985306 2019
Entrez Id: 4005
Gene Symbol: LMO2
LMO2
0.010 Biomarker disease BEFREE LMO2 gene deletions significantly worsen the prognosis of Wilms' tumor development in patients with WAGR syndrome. 31304537 2019
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
0.010 Biomarker disease BEFREE These results indicated that HNF1β may play important roles in kidney development and function, and its activation may negatively regulate Wilms' tumor progression. 31038395 2019
Entrez Id: 100302179
Gene Symbol: MIR1270
MIR1270
0.010 Biomarker disease BEFREE The correlation between hsa-miR-1270 and Wilms' tumor gene (<i>WT1</i>) was probed by dual-luciferase activity assay, qRT-PCR, and Western blot. 31417281 2019
Entrez Id: 4804
Gene Symbol: NGFR
NGFR
0.010 Biomarker disease BEFREE Only a minority of WT stained for NGFR: 16% showed expression in the blastemal and 25% in the mesenchymal components. 28426529 2019
Entrez Id: 3191
Gene Symbol: HNRNPL
HNRNPL
0.010 Biomarker disease BEFREE HnRNPL promotes Wilms tumor progression by regulating the p53 and Bcl2 pathways. 31213844 2019
Entrez Id: 6732
Gene Symbol: SRPK1
SRPK1
0.010 Biomarker disease BEFREE In podocytes, the Wilms' tumor suppressor 1 (WT1) suppresses the Serine/arginine-rich protein-specific splicing factor kinase (SRPK1), and indirectly Serine/arginine-rich splicing factor 1 (Srsf1) activity, and alters VEGF splicing. 30641926 2019