Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 Biomarker disease BEFREE We investigated pain sensitivity in humans with WAGR (Wilms tumor, aniridia, genitourinary anomaly, and range of intellectual disabilities) syndrome, who have variably sized heterozygous deletion of the 11p13 region. 30855519 2019
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 GeneticVariation disease BEFREE Our previous study of congenital aniridia patients revealed a noticeable number of aniridia patients with WAGR-region deletions but without Wilms' tumor in their medical history. 31304537 2019
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 GeneticVariation disease BEFREE Germline mutations in the WT1 gene have been identified in some families with Wilms tumor. 29292210 2018
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 GeneticVariation disease BEFREE In the present study, combination vaccine of Wilms' tumor gene 1(WT1) protein-derived CTL and helper peptides induced the strong infiltration of WT1-specific CD8<sup>+</sup> T cells into mouse tumor at frequencies of 8.8%, resulting in the formation of multiple microscopic necrotic lesions in the tumor, whereas the frequencies of WT1-specific CD8<sup>+</sup> T cell infiltration into the tumor in the vaccination of the CTL peptide alone were only 0.32%. 30542516 2018
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 GeneticVariation disease BEFREE All described patients presented with similar neuroimaging features including thin corpus callosum, mild to moderate cerebellar atrophy and diffuse periventricular and profound hypomyelinating leukodystrophy involving supratentorial white matter with classical compromise linked to inherited non-somatic WT1 gene mutations in a similar pattern to Denys-Drash syndrome, including nephrotic syndrome with different glomerular disease, chronic renal failure, intersex disorder with ambiguous genitalia, and early occurrence of specific tumors, such as Wilms' tumor and gonadoblastoma. 29801916 2018
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 Biomarker disease BEFREE Anti-apoptotic quinolinate phosphoribosyltransferase (QPRT) is a target gene of Wilms' tumor gene 1 (WT1) protein in leukemic cells. 27889611 2017
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 Biomarker disease BEFREE These 5 animals presented tumors with histology and cells highly staining positive for PCNA and Wilms' tumor protein antibody characteristics of Wilms' tumor. 28845162 2017
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 Biomarker disease BEFREE The identification of human Wilms' tumor gene 1 (WT1) protein-derived cytotoxic T lymphocyte (CTL) epitopes and the in vivo efficacy of WT1 peptide-based immunotherapy in a mouse model were reported in 2000. 29041012 2017
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 Biomarker disease BEFREE WT4869 is a synthetic peptide vaccine derived from the Wilms' tumor gene 1 (WT1) protein. 28949050 2017
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 Biomarker disease BEFREE The Wilms' tumor 1 gene (WT1) was originally isolated and described as the gene responsible for Wilms' tumor. 27665981 2016
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 Biomarker disease BEFREE Wilms' tumor gene 1 (WT1) protein is a promising tumor-associated antigen for cancer immunotherapy. 25835542 2015
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 GeneticVariation disease BEFREE Interstitial deletions of the 11p13 region are known to cause WAGR (Wilms tumor, aniridia, genitourinary malformation, and "mental retardation") syndrome, a contiguous gene deletion syndrome due to haploinsufficiencies of the genes in this region, including WT1 and PAX6. 24357251 2014
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 Biomarker disease BEFREE An amplified exon 9 sequence of the WT1 gene showing similarity with exon 9 of TV-A, F and exon 10 of TV-B, D and E with a deletion of single nucleotide 'A' causing frame shift in the 4th zinc finger domain of the WT1 protein resulted in Wilms' tumor condition. 24853201 2014
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 Biomarker disease BEFREE Mutations in WT1 are observed in 20% of Wilms tumors (a pediatric kidney cancer), but the in vivo WT1 targets and associated molecular pathways involved in the etiology of Wilms tumor are still elusive. 23291318 2013
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 GeneticVariation disease BEFREE Newborn sporadic aniridia patients with an 11p13 deletion including the WT1 gene have an increased risk to develop Wilms tumor. 23494989 2013
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 Biomarker disease BEFREE Wilms' tumor gene 1 (WT1) protein is a promising tumor-associated antigen. 22126448 2012
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 GeneticVariation disease BEFREE Identification and analysis of mutations in WTX and WT1 genes in peripheral blood and tumor tissue of children with Wilms' tumor. 22800892 2012
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 GeneticVariation disease BEFREE The WAGR contiguous gene deletion syndrome is a combination of Wilms tumor, aniridia, genito-urinary abnormalities, and mental retardation. 21660403 2011
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 GeneticVariation disease BEFREE A novel WT1 gene mutation in a patient with Wilms' tumor and 46, XY gonadal dysgenesis. 21384108 2011
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 GeneticVariation disease BEFREE Although the WT1 gene, located at 11p13, has been proven to be implicated in the development of Wilms tumor, other genes such as MYCN are also involved. 20186010 2010
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 Biomarker disease BEFREE The lack of Wilms tumor or other related phenotypes suggests the expansion of WT1 gene analysis in patients with focal segmental glomerulosclerosis, regardless of age or presence of typical Denys-Drash or Frasier syndrome clinical features. 20150449 2010
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 GeneticVariation disease BEFREE Wilms' tumor gene 1 (WT1) gene expression was analyzed in 32 patient with acute myeloid leukemia (AML) and 18 with acute lymphoblastic leukemia (ALL) to investigate whether it could serve as a MRD marker. 19811333 2009
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 GeneticVariation disease BEFREE We demonstrate abundant PAX3 and absence of PAX2 expression in a novel cell line (WitP3) isolated from the stromal portion of a WT bearing a homozygous deletion of the WT1 gene. 18666806 2009
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 GeneticVariation disease BEFREE Although the majority of congenital urogenital abnormalities are not due to constitutional defects of the WT1 gene, our findings provide a rational for considering WT1 mutational analysis as one of the screening options in newborns with congenital defects of the urogenital tract due to the associated high risk of WT. 19048299 2009
Entrez Id: 7490
Gene Symbol: WT1
WT1
0.100 AlteredExpression disease BEFREE Knockdown of WT1 protein by siRNA significantly increased the cellular renin mRNA content, while overexpression of WT1(-KTS) reduced renin gene expression in stable and transiently transfected cells. 18496514 2008