Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 79727
Gene Symbol: LIN28A
LIN28A
0.250 Biomarker disease BEFREE LIN28, a Wilms tumor oncoprotein, triggers the DIS3L2-mediated degradation of the precursor of let-7, a microRNA that inhibits Wilms tumor development. 29950491 2018
Entrez Id: 79727
Gene Symbol: LIN28A
LIN28A
0.250 AlteredExpression disease BEFREE Previous studies indicated that Lin28 homolog B (LIN28B) level is significantly elevated in some WTs. 28301057 2018
Entrez Id: 79727
Gene Symbol: LIN28A
LIN28A
0.250 AlteredExpression disease BEFREE The relationship of specific miRNAs, such as the miR-17∼92 cluster and cystic kidney disease, miR-92a and von Hippel-Lindau syndrome, and alterations in LIN28-LET7 expression in Wilms tumor will be explored. 25490692 2015
Entrez Id: 79727
Gene Symbol: LIN28A
LIN28A
0.250 Biomarker disease BEFREE Interestingly, Lin28, a direct target of miRNA let-7 and potent regulator of stem cell self-renewal and differentiation, is significantly elevated in some Wilms tumors, and enforced expression of Lin28 during kidney development could induce Wilms tumor. 25018051 2014
Entrez Id: 79727
Gene Symbol: LIN28A
LIN28A
0.250 Biomarker disease BEFREE Using lineage-specific promoters to target Lin28 to specific cell types, we observed Wilms tumor only when Lin28 is aberrantly expressed in multiple derivatives of the intermediate mesoderm, implicating the cell of origin as a multipotential renal progenitor. 24732380 2014
Entrez Id: 79727
Gene Symbol: LIN28A
LIN28A
0.250 Biomarker disease MGD