Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.630 GeneticVariation disease UNIPROT
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.630 Biomarker disease CTD_human
Entrez Id: 3815
Gene Symbol: KIT
KIT 		0.630 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 2261
Gene Symbol: FGFR3
FGFR3 		0.500 Biomarker disease CTD_human
Entrez Id: 6794
Gene Symbol: STK11
STK11 		0.500 Biomarker disease CTD_human
Entrez Id: 8915
Gene Symbol: BCL10
BCL10 		0.310 Biomarker disease CTD_human
Entrez Id: 7371
Gene Symbol: UCK2
UCK2 		0.110 GeneticVariation disease BEFREE Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23. 23462292 2013
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.020 Biomarker disease BEFREE PTEN appears to be essential for germ cell differentiation and an important factor in testicular germ cell tumor formation. 12620992 2003
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.010 AlteredExpression disease BEFREE CDH1 serum levels may be a serological marker for staging of TGCT patients. 16907861 2006
Entrez Id: 4254
Gene Symbol: KITLG
KITLG 		0.150 Biomarker disease BEFREE KITLG, encoding the ligand for the receptor tyrosine kinase KIT, which has previously been implicated in the pathogenesis of TGCT and the biology of germ cells, may explain the association on chromosome 12. 19483681 2009
Entrez Id: 283297
Gene Symbol: OR10A4
OR10A4 		0.010 Biomarker disease BEFREE HP-2 and HP-14 effectively inhibited the growth of VEGFR-2-expressing TGCT cell lines (Tera-1, Tera-2 and 2102EP) and endothelial cell models, while they failed to supress the growth of VEGFR-2-lacking tumour cells. cDNA-microarrays revealed an inhibition of the expression of several growth factor receptors and related signal transduction molecules. 20551952 2010
Entrez Id: 29947
Gene Symbol: DNMT3L
DNMT3L 		0.010 AlteredExpression disease BEFREE DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor. 26917601 2016
Entrez Id: 123872
Gene Symbol: DNAAF1
DNAAF1 		0.010 GeneticVariation disease BEFREE DNAAF1 mutation as a cause of TGCT is supported by a dnaaf1<sup>hu255h</sup>(+/-) zebrafish model, which has a 94% risk of TGCT. 27996046 2016
Entrez Id: 4255
Gene Symbol: MGMT
MGMT 		0.020 PosttranslationalModification disease BEFREE MGMT and CALCA promoter methylation are associated with poor prognosis in testicular germ cell tumor patients. 28881587 2017
Entrez Id: 29842
Gene Symbol: TFCP2L1
TFCP2L1 		0.110 Biomarker disease BEFREE TFCP2L1 joins the growing list of genes located within TGCT risk loci with biologically plausible roles in developmental transcriptional regulation, further highlighting the importance of this phenomenon in TGCT oncogenesis. 29560096 2018
Entrez Id: 6899
Gene Symbol: TBX1
TBX1 		0.010 Biomarker disease BEFREE Brachyury cytoplasm immunostaining was present in 89.6% (86/96) of cases with nuclear staining observed in 24% (23/96) of testicular germ cell tumor. 29749711 2018
Entrez Id: 3855
Gene Symbol: KRT7
KRT7 		0.010 Biomarker disease BEFREE Cytokeratin 7, inhibin, and p63 in testicular germ cell tumor: superior markers of choriocarcinoma compared to β-human chorionic gonadotropin. 30359635 2019
Entrez Id: 11186
Gene Symbol: RASSF1
RASSF1 		0.020 PosttranslationalModification disease BEFREE RASSF1A and MGMT methylation was noted in 58.5% and 10% of the TGCTs. 31653608 2020
Entrez Id: 4254
Gene Symbol: KITLG
KITLG 		0.150 GeneticVariation disease GWASDB A genome-wide association study of testicular germ cell tumor. 19483681 2009
Entrez Id: 578
Gene Symbol: BAK1
BAK1 		0.110 GeneticVariation disease GWASDB A genome-wide association study of testicular germ cell tumor. 19483681 2009
Entrez Id: 449520
Gene Symbol: GGNBP1
GGNBP1 		0.100 GeneticVariation disease GWASDB A genome-wide association study of testicular germ cell tumor. 19483681 2009
Entrez Id: 174
Gene Symbol: AFP
AFP 		0.030 Biomarker disease BEFREE A human testicular germ cell tumor with borderline histology between seminoma and embryonal carcinoma secreted beta-human chorionic gonadotropin and alpha-fetoprotein only as a xenograft. 2423223 1986
Entrez Id: 1435
Gene Symbol: CSF1
CSF1 		0.050 Biomarker disease BEFREE A miR-125b/CSF1-CX3CL1/tumor-associated macrophage recruitment axis controls testicular germ cell tumor growth. 30237497 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.060 Biomarker disease BEFREE A miR-199a/miR-214 self-regulatory network via PSMD10, TP53 and DNMT1 in testicular germ cell tumor. 25231260 2014
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1 		0.020 Biomarker disease BEFREE A miR-199a/miR-214 self-regulatory network via PSMD10, TP53 and DNMT1 in testicular germ cell tumor. 25231260 2014