Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
0.130 GeneticVariation disease GWASCAT Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer. 28703219 2017
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
0.130 GeneticVariation disease BEFREE In addition, we confirmed three previously reported loci (FOXE1, NKX2-1 and DIRC3) and identified seven novel susceptibility loci (VAV3, PCNXL2, INSR, MRSB3, FHIT, SEPT11 and SLC24A6) associated with DTC. 28703219 2017
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
0.130 GeneticVariation disease BEFREE Genome-wide association studies (GWASs) on differentiated thyroid cancer (DTC) have identified robust associations with single nucleotide polymorphisms (SNPs) at 9q22.33 (FOXE1), 14q13.3 (NKX2-1), and 2q35 (DIRC3). 25029422 2014
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3
0.130 GeneticVariation disease BEFREE Genome-wide association studies (GWASs) of differentiated thyroid cancer (DTC) have identified associations with polymorphisms at 2q35 (DIRC3), 8p12 (NRG1), 9q22.33 (FOXE1), and 14q13.2 (NKX2-1). 23894154 2013
Entrez Id: 3084
Gene Symbol: NRG1
NRG1
0.110 GeneticVariation disease GWASCAT Genome-wide association and expression quantitative trait loci studies identify multiple susceptibility loci for thyroid cancer. 28703219 2017
Entrez Id: 3084
Gene Symbol: NRG1
NRG1
0.110 GeneticVariation disease BEFREE Genome-wide association studies (GWASs) of differentiated thyroid cancer (DTC) have identified associations with polymorphisms at 2q35 (DIRC3), 8p12 (NRG1), 9q22.33 (FOXE1), and 14q13.2 (NKX2-1). 23894154 2013
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE To discuss advances and challenges in thyroglobulin and Tg-antibody (TgAb) measurement and their impact on clinical management of differentiated thyroid carcinoma (DTC). 31599768 2020
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE This is an institutional review board-approved retrospective study of patients who underwent lymph node fine needle aspiration biopsy with thyroglobulin washout between 2012 and 2018, during the post-total thyroidectomy follow-up of differentiated thyroid cancer. 31495510 2020
Entrez Id: 110806263
Gene Symbol: LOC110806263
LOC110806263
0.100 GeneticVariation disease BEFREE Association between TERT promoter mutations and clinical behaviors in differentiated thyroid carcinoma: a systematic review and meta-analysis. 31655978 2020
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 Biomarker disease BEFREE Clinical records were reviewed and tissue specimens were genetically tested for the presence of the most commonly encountered mutational markers in differentiated thyroid cancer: BRAF, N-RAS, and H-RAS. 31586312 2019
Entrez Id: 23583
Gene Symbol: SMUG1
SMUG1
0.100 Biomarker disease BEFREE A trend toward a significant association was also found between positive 18F-FDG-PET/CT and both Tg-DT <12 months and DTC aggressive subtypes. 30864903 2019
Entrez Id: 23583
Gene Symbol: SMUG1
SMUG1
0.100 Biomarker disease BEFREE We investigated the usefulness of FDG PET/CT for the early prediction of RAI therapy response in the patients with metastatic differentiated thyroid cancer (DTC). 31237886 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 AlteredExpression disease BEFREE A higher elevation of Tg levels after RAI may be associated with a better treatment outcome in DTC patients with distant metastasis. 30382500 2019
Entrez Id: 6528
Gene Symbol: SLC5A5
SLC5A5
0.100 AlteredExpression disease BEFREE In the present study, we added ascorbic acid (AA) to <sup>211</sup>At solution to increase the radiochemical purity of astatide and evaluated its efficacy against differentiated thyroid cancer, which is characterized by the expression of sodium/iodide symporter (NIS). 30796173 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE <b>Background:</b> In patients with differentiated thyroid cancer (DTC) and raising serum thyroglobulin (Tg) after total or near-total thyroidectomy and <sup>131</sup>I remnant ablation an empiric <sup>131</sup>I therapy may be considered. 30930852 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE There is literature evidence showing utility of somatostatin receptor (SSTR) positron emission tomography-CT (PET-CT) imaging in differentiated thyroid cancer with Thyroglobulin Elevated and Negative Iodine Scan (TENIS). 30940668 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE Radioiodine Uptake and Thyroglobulin-Guided Radioiodine Remnant Ablation in Patients with Differentiated Thyroid Cancer: A Prospective, Randomized, Open-Label, Controlled Trial. 30560716 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE To evaluate the accuracy of 18F-FDG-PET/CT for detection of recurrent and/or metastatic diseases in differentiated thyroid cancer (DTC) patients with thyroglobulin elevation and negative iodine scintigraphy. 31117054 2019
Entrez Id: 23583
Gene Symbol: SMUG1
SMUG1
0.100 AlteredExpression disease BEFREE The relationship between F-FDG uptake in the pituitary gland and serum TSH levels was evaluated the in DTC patients, and the pituitary F-FDG metabolism was compared in different thyroid status. 30422898 2019
Entrez Id: 10848
Gene Symbol: PPP1R13L
PPP1R13L
0.100 Biomarker disease BEFREE <b>Abbreviations: BM</b> = bone metastases; <b>COX</b> = multivariate analyses; <b>DM</b> = distant metastases; <b>DSM</b> = disease-specific mortality; <b>DSS</b> = disease-specific survival; <b>DTC</b> = differentiated thyroid carcinoma; <b>ETE</b> = extrathyroidal extension; <b>LNM</b> = lymph node metastases; <b>OM</b> = overall mortality; <b>OS</b> = overall survival; <b>PTCFV</b> = papillary thyroid carcinoma; <b>RAI</b> = radioactive iodine; <b>SM</b> = spinal metastases; <b>SRE</b> = skeletal-related event; <b>txWBS</b> = whole-body scan after RAI therapy. 30657361 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE Moreover, TgAb in different concentrations had an effect on the diagnosis of metastasis of differentiated thyroid cancer via Tg. 29442477 2019
Entrez Id: 10848
Gene Symbol: PPP1R13L
PPP1R13L
0.100 Biomarker disease BEFREE According to our program of TKI dose reduction and withdrawal, all patients except 2 with diabetes were successfully continuing treatment.Overall, the present results demonstrated that renal function is negatively affected by long-term TKI treatment for RAI-refractory DTC. 31626129 2019
Entrez Id: 53358
Gene Symbol: SHC3
SHC3
0.100 Biomarker disease BEFREE According to our program of TKI dose reduction and withdrawal, all patients except 2 with diabetes were successfully continuing treatment.Overall, the present results demonstrated that renal function is negatively affected by long-term TKI treatment for RAI-refractory DTC. 31626129 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE Definition of the Response to Initial Therapy with Radioiodine in Patients with Differentiated Thyroid Carcinoma: Basal or Stimulated Thyroglobulin? 31578049 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 GeneticVariation disease BEFREE We conducted a real-world comparison to assess the outcome of low-risk TC (AJCC stage I) with undetectable thyroglobulin (TG) 2 years after radio-iodine (I-131) therapy. 31602364 2019