Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10611
Gene Symbol: PDLIM5
PDLIM5
0.010 Biomarker phenotype BEFREE Age-matched groups of older adults with either age-appropriate hearing (ENH, <i>n</i> = 20) or aided hearing impairment (EHI, <i>n</i> = 21) participated. 29867654 2018
Entrez Id: 213
Gene Symbol: ALB
ALB
0.010 Biomarker phenotype BEFREE There were statistically significant differences between hearing impairment versus normal hearing for vitamin D [19.40±9.71 ng/ml versus 22.67±9.28 ng/ml; p<0.001], calcium, magnesium, phosphorous, cholesterol, HDL-C, LDL-C, albumin, systolic blood pressure [131.70±9.25 Hg versus 127.73±11.98 Hg], diastolic blood pressure [82.20±8.60 mm Hg versus 79.80±8.20 mm Hg], and microalbuminuria. 30112372 2018
Entrez Id: 5351
Gene Symbol: PLOD1
PLOD1
0.010 Biomarker phenotype BEFREE We show that myopathy is confirmed by histology and muscle imaging only in some patients, and that hearing impairment is predominantly sensorineural and may not be present in all individuals.ConclusionOur data further support the extensive clinical overlap with PLOD1-kEDS and show that vascular complications are rare manifestations of FKBP14-kEDS. 28617417 2018
Entrez Id: 6094
Gene Symbol: ROM1
ROM1
0.010 Biomarker phenotype BEFREE Hearing loss or hearing impairment may induce inappropriate postural strategies that could affect balance and therefore increase the risk of falling.The aim of this study was to understand whether hearing loss could influence balance, cervical posture, and muscle activation in the cervical region.Thirteen patients (61 ± 13 years; 161.8 ± 11.0 cm; 70.5 ± 15.9 kg) with moderate hearing loss (Right ear -60 ± 21 dB; Left ear -61 ± 24 dB) underwent: an audiometric examination, a postural examination (with open and closed eyes) through a stabilometric platform, a cervical ROM examination through a head accelerometer, and a sternocleidomastoid electromyography (EMG) examination.A linear regression analysis has shown a regression coefficient (R) 0.76 and 0.69 between hearing loss and the posturographic parameters, on the sagittal sway, with open and closed eyes, respectively. 29620637 2018
Entrez Id: 54974
Gene Symbol: THG1L
THG1L
0.010 Biomarker phenotype BEFREE Decreased Expression of TRPV4 Channels in HEI-OC1 Cells Induced by High Glucose Is Associated with Hearing Impairment. 30328329 2018
Entrez Id: 7439
Gene Symbol: BEST1
BEST1
0.010 Biomarker phenotype BEFREE Twenty-seven articles were identified, including 26 candidate gene studies: metabolic syndrome (n = 6); BMD (n = 6); gonadal impairment (n = 2); hearing impairment (n = 12) and one GWAS (metabolic syndrome). 29759558 2018
Entrez Id: 2309
Gene Symbol: FOXO3
FOXO3
0.010 Biomarker phenotype BEFREE FOXO3 knockout mice have impaired hearing which may be due to defects in synapse localization within the ear. 29433734 2018
Entrez Id: 1756
Gene Symbol: DMD
DMD
0.010 Biomarker phenotype BEFREE Twenty-seven articles were identified, including 26 candidate gene studies: metabolic syndrome (n = 6); BMD (n = 6); gonadal impairment (n = 2); hearing impairment (n = 12) and one GWAS (metabolic syndrome). 29759558 2018
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
0.010 Biomarker phenotype BEFREE These findings point to a new mechanism by which miR-34a exerts its detrimental effects by negatively regulating SIRT1/HIF-1α signaling and provide new therapeutic targets for treating hearing impairment during diabetes. 28263817 2017
Entrez Id: 6296
Gene Symbol: ACSM3
ACSM3
0.010 Biomarker phenotype BEFREE Audiometric tests, auditory cognitive assessments, and follow-up studies are needed to determine the cause and prognosis of hearing impairment after SAH. 28017208 2017
Entrez Id: 7389
Gene Symbol: UROD
UROD
0.010 AlteredExpression phenotype BEFREE The levels of PCT and CD64 in cerebrospinal fluid of children with hearing impairment were significantly higher than those of children with normal hearing (P<0.01). 29285148 2017
Entrez Id: 796
Gene Symbol: CALCA
CALCA
0.010 AlteredExpression phenotype BEFREE The levels of PCT and CD64 in cerebrospinal fluid of children with hearing impairment were significantly higher than those of children with normal hearing (P<0.01). 29285148 2017
Entrez Id: 2209
Gene Symbol: FCGR1A
FCGR1A
0.010 AlteredExpression phenotype BEFREE The levels of PCT and CD64 in cerebrospinal fluid of children with hearing impairment were significantly higher than those of children with normal hearing (P<0.01). 29285148 2017
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.010 Biomarker phenotype BEFREE These findings point to a new mechanism by which miR-34a exerts its detrimental effects by negatively regulating SIRT1/HIF-1α signaling and provide new therapeutic targets for treating hearing impairment during diabetes. 28263817 2017
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.010 GeneticVariation phenotype BEFREE Phenome-wide association study for CYP2A6 alleles: rs113288603 is associated with hearing loss symptoms in elderly smokers. 28432340 2017
Entrez Id: 5265
Gene Symbol: SERPINA1
SERPINA1
0.010 Biomarker phenotype BEFREE <b>Conclusion:</b> The utilized questionnaire (ABQ), together with AAT and THI, can help to study comorbid hearing impairments in patients regularly attending an audiological clinic. 28428741 2017
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.010 GeneticVariation phenotype BEFREE Expression levels of the BAK1 and BCL2 genes highlight the role of apoptosis in age-related hearing impairment. 27555755 2016
Entrez Id: 578
Gene Symbol: BAK1
BAK1
0.010 GeneticVariation phenotype BEFREE Expression levels of the BAK1 and BCL2 genes highlight the role of apoptosis in age-related hearing impairment. 27555755 2016
Entrez Id: 7039
Gene Symbol: TGFA
TGFA
0.010 GeneticVariation phenotype BEFREE BACKGROUND The aim of this study was to investigate whether the TGFA/TGFB3/MSX1 gene polymorphisms and haplotypes lead to individual differences between congenital non-syndromic hearing impairment (NSHI) patients and normal people in a Chinese population and to analyze the risk factors for NSHI. 27356075 2016
Entrez Id: 7043
Gene Symbol: TGFB3
TGFB3
0.010 GeneticVariation phenotype BEFREE BACKGROUND The aim of this study was to investigate whether the TGFA/TGFB3/MSX1 gene polymorphisms and haplotypes lead to individual differences between congenital non-syndromic hearing impairment (NSHI) patients and normal people in a Chinese population and to analyze the risk factors for NSHI. 27356075 2016
Entrez Id: 4487
Gene Symbol: MSX1
MSX1
0.010 GeneticVariation phenotype BEFREE Associations Between TGFA/TGFB3/MSX1 Gene Polymorphisms and Congenital Non-Syndromic Hearing Impairment in a Chinese Population. 27356075 2016
Entrez Id: 2113
Gene Symbol: ETS1
ETS1
0.010 Biomarker phenotype BEFREE Our findings indicate that the short nose, otitis media, and hearing impairment in Jacobsen syndrome are likely because of hemizygosity for ETS1 and FLI1. 26093983 2015
Entrez Id: 8763
Gene Symbol: CD164
CD164
0.010 Biomarker phenotype BEFREE In conclusion, we have identified a new DFNA locus located on chromosome 6q15-21 and implicated CD164 as a novel gene for hearing impairment. 26197441 2015
Entrez Id: 2313
Gene Symbol: FLI1
FLI1
0.010 Biomarker phenotype BEFREE Our findings indicate that the short nose, otitis media, and hearing impairment in Jacobsen syndrome are likely because of hemizygosity for ETS1 and FLI1. 26093983 2015
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.010 Biomarker phenotype BEFREE Contribution of adiponectin and its type 1 receptor to age-related hearing impairment. 25911279 2015