Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 16
Gene Symbol: AARS1
AARS1
0.010 Biomarker disease BEFREE Severe disruption of the editing activity of AlaRS caused embryonic lethality, whereas an intermediate reduction in AlaRS editing efficacy resulted in ubiquitinated protein aggregates and mitochondrial defects in cardiomyocytes that were accompanied by progressive cardiac fibrosis and dysfunction. 25422440 2014
Entrez Id: 57505
Gene Symbol: AARS2
AARS2
0.010 Biomarker disease BEFREE Severe disruption of the editing activity of AlaRS caused embryonic lethality, whereas an intermediate reduction in AlaRS editing efficacy resulted in ubiquitinated protein aggregates and mitochondrial defects in cardiomyocytes that were accompanied by progressive cardiac fibrosis and dysfunction. 25422440 2014
Entrez Id: 368
Gene Symbol: ABCC6
ABCC6
0.010 Biomarker disease BEFREE Abcc6 is a previously unrecognized player in the development of stress-induced cardiac fibrosis. 25480693 2015
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.050 Biomarker disease BEFREE Moreover early treatment of UUO/CKD animals with an angiotensin-converting-enzyme inhibitor (ACE I), Enalapril, significantly attenuated cardiac fibrosis. 30382174 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.050 GeneticVariation disease BEFREE The angiotensin-converting enzyme (ACE) deletion allele, ACE D, is associated with increased cardiac ACE activity, cardiac fibrosis, and adverse outcomes in cardiovascular disease and has been linked with failure of antiatrial fibrillation (anti-AF) drug treatment. 23876437 2013
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.050 AlteredExpression disease BEFREE The loss of apelin increased the ratio of angiotensin-converting enzyme (ACE) to ACE2 expression in the Ang II-stressed hearts, and Ang II-induced cardiac fibrosis was markedly enhanced in apelin knockout mice. mRNA expression of pro-fibrotic genes, such as transforming growth-factor beta (TGF-β) signaling, were significantly upregulated in apelin knockout hearts. 30634441 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.050 Biomarker disease BEFREE Chronic treatment with angiotensin-converting enzyme inhibitor increases cardiac fibrosis in young rats submitted to early ovarian failure. 28712539 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.050 Biomarker disease BEFREE Angiotensin converting enzyme (ACE) promotes cardiac fibrosis. 27787699 2017
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.220 AlteredExpression disease BEFREE The effect of fluvastatin on cardiac fibrosis and angiotensin-converting enzyme-2 expression in glucose-controlled diabetic rat hearts. 28013371 2017
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.220 Therapeutic disease RGD Angiotensin-converting enzyme 2 activation protects against hypertension-induced cardiac fibrosis involving extracellular signal-regulated kinases. 21148624 2011
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.220 AlteredExpression disease BEFREE The loss of apelin increased the ratio of angiotensin-converting enzyme (ACE) to ACE2 expression in the Ang II-stressed hearts, and Ang II-induced cardiac fibrosis was markedly enhanced in apelin knockout mice. mRNA expression of pro-fibrotic genes, such as transforming growth-factor beta (TGF-β) signaling, were significantly upregulated in apelin knockout hearts. 30634441 2019
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3
0.010 Biomarker disease BEFREE Discovery of a Novel Small-Molecule Modulator of C-X-C Chemokine Receptor Type 7 as a Treatment for Cardiac Fibrosis. 29627981 2018
Entrez Id: 60
Gene Symbol: ACTB
ACTB
0.050 Biomarker disease BEFREE Ang II infusion induced cardiac injury, including increased macrophage infiltration, expression of inflammatory cytokines (IL-12, IL-6, etc), and cardiac fibrosis, such as elevated α-smooth muscle actin, collagen I, and TGF-β expression. 24877626 2014
Entrez Id: 60
Gene Symbol: ACTB
ACTB
0.050 AlteredExpression disease BEFREE The aim of the present study was to investigate the mechanisms of CCAAT/enhancer-binding protein β (C/EBPβ) in cardiac myofibroblast (CMF) differentiation and in a rat model of cardiac fibrosis induced by experimental autoimmune myocarditis (EAM).In vitro studies performed in primary neonatal rat CMF revealed that silencing of C/EBPβ expression (via lentiviral mediated shRNA strategies) was sufficient to reduce C/EBPβ mRNA and protein levels as well as to decrease the expressions of actin cytoskeletal proteins, cofilin, and filamin A (FLNA). 30305575 2018
Entrez Id: 60
Gene Symbol: ACTB
ACTB
0.050 AlteredExpression disease BEFREE Flow cytometry analysis was performed to identify cardiac fibroblasts by examining vimentin, fibronectin (FN) and α-actin expression in human CFs. qRT-PCR and western blot assays were performed to confirm the expression of miR-32-5p, DUSP1 and cardiac fibrosis relevant proteins. 31438862 2019
Entrez Id: 60
Gene Symbol: ACTB
ACTB
0.050 AlteredExpression disease BEFREE Peri-transplant surgical trauma and ischemia/reperfusion injury in accepted murine heterotopic heart grafts has been associated with myofibroblast differentiation, cardiac fibrosis and biomechanical-stress activation of the fetal myocardial smooth muscle α-actin (SMαA) gene. 22619371 2012
Entrez Id: 60
Gene Symbol: ACTB
ACTB
0.050 Biomarker disease BEFREE Compared with the wild-type mice, although Ang II infusion caused an equally high systolic blood pressure, levels of human CRP were further elevated, and cardiac remodeling was markedly exacerbated in mice that express human CRP, resulting in a significant reduction in the left ventricular ejection fraction and fractional shortening and an increase in cardiac fibrosis (collagen I and III and alpha-smooth muscle actin) and inflammation (interleukin 1beta and tumor necrosis factor-alpha). 20157054 2010
Entrez Id: 91
Gene Symbol: ACVR1B
ACVR1B
0.010 Biomarker disease BEFREE These results indicate that partial inhibition of ALK4 may reduce MI-induced CF, suggesting ALK4 as a novel target for inhibition of unfavorable CF and for preservation of LV systolic function induced by not only pressure-overload but also MI. 28214509 2017
Entrez Id: 94
Gene Symbol: ACVRL1
ACVRL1
0.010 AlteredExpression disease BEFREE Reduced activin receptor-like kinase 1 activity promotes cardiac fibrosis in heart failure. 28820968 2018
Entrez Id: 170690
Gene Symbol: ADAMTS16
ADAMTS16
0.010 Biomarker disease BEFREE In this study, we aimed to establish ADAMTS16 as a key regulator of cardiac fibrosis. 31297506 2020
Entrez Id: 64123
Gene Symbol: ADGRL4
ADGRL4
0.010 Biomarker disease BEFREE ELTD1 deficiency exacerbates cardiac hypertrophy and cardiac function induced by AB-induced pressure overload by promoting both cardiomyocyte hypertrophy and cardiac fibrosis. 22606234 2012
Entrez Id: 133
Gene Symbol: ADM
ADM
0.010 Biomarker disease BEFREE Previous studies of the authors have indicated that the transplantation of mesenchymal stem cells (MSCs) can attenuate cardiac fibrosis through the secretion of antifibrotic factors, such as adrenomedullin (ADM). 29138835 2018
Entrez Id: 153
Gene Symbol: ADRB1
ADRB1
0.010 AlteredExpression disease BEFREE However, deletion of HuR in cardiomyocytes mitigated the effect of ISO in inducing PLB expression and reducing β1-AR expression, in turn aggravating ISO-induced myocardial hypertrophy and cardiac fibrosis. 31373621 2020
Entrez Id: 177
Gene Symbol: AGER
AGER
0.210 Therapeutic disease RGD Calcitriol modulates receptor for advanced glycation end products (RAGE) in diabetic hearts. 24630381 2014
Entrez Id: 177
Gene Symbol: AGER
AGER
0.210 Biomarker disease BEFREE It has been reported that receptor for advanced glycation end-products (RAGE) plays a significant role in cardiac fibrosis. 27372036 2016