Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 AlteredExpression disease BEFREE TAC administration induced cardiac fibrosis and heart weight increase, which was associated with the induced expressions of TGF-β1, miR-143-3p, p-Smad2, and collagens. 31758917 2020
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 AlteredExpression disease BEFREE However, anti-TLR2 antibody alleviated masson staining area, levels of TGF-β1 and Collagen I mRNA, and decreased TUNEL-positive myocardial cells and caspase-3 activity, suggesting that anti-TLR2 antibody protected cardiac cells against high-fat-induced cardiac fibrosis and cell apoptosis. 30877771 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 AlteredExpression disease BEFREE This proof-of-concept study using an in vitro experimental cell culture model identifies the protective role of simvastatin against TGF-β1-induced hVF transformation into activated myofibroblasts through activation of protein phosphatase, a novel target that can be therapeutically modulated to curb excessive cardiac fibrosis associated with maladaptive cardiac remodeling. 30220377 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE A recent study reported that deficiency of miR-378a contributes to cardiac fibrosis via TGF-β1-dependent paracrine mechanism. 27855367 2016
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE These data indicate that NE enhances cardiac fibrosis through TGF-beta1 post-receptor signaling, predominantly via the p38 MAP kinase pathway. 12154105 2002
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE TGFβ1 is a key cytokine mediating cardiac fibrosis. 28230250 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE AT‑II induces periostin expression by regulating transforming growth factor‑β1 (TGF‑β1)/Smad signaling during cardiac fibrosis. 28849131 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 AlteredExpression disease BEFREE This study demonstrates a novel transgenic goat model of cardiac fibrosis (TGF-β1 overexpression) to demonstrate that endurance exercise in the setting of an underlying atrial myopathy increases the incidence of spontaneous AF. 31707807 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE The axis of local cardiac endogenous Klotho-TGF-β1-Wnt signaling mediates cardiac fibrosis in human. 31520610 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 AlteredExpression disease BEFREE Expression levels of IL-33/ST2 pathway factors in myocardial tissue were significantly associated with cardiac fibrosis and the expression levels of CTGF and TGFβ1. 29285671 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE In conclusion, the results of the present study demonstrated that TGF‑β1/Smad signaling‑associated cardiac fibrosis is involved in the impairment of heart compliance and LV dysfunction in DbCM. 29138820 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE There is a close relationship between transforming growth factor-β1 mediated cardiac fibrosis and acquired arrhythmia. 27380173 2016
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE Atrial fibrillation (AF) rat models and rat cardiac fibroblasts (CFs) with overexpressed or inhibited miR-10a were used to investigate the possible role of miR-10a-mediated transforming growth factor-β (TGF-β1)/Smads signaling in cardiac fibrosis and fibroblast proliferation in rats with AF. 30683806 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE Asiatic acid inhibits cardiac fibrosis throughNrf2/HO-1 and TGF-β1/Smads signaling pathways in spontaneous hypertension rats. 31254954 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE TGF-beta1 is involved in pathologic states such as cardiac hypertrophy and cardiac fibrosis; we thus postulate that the TGF-beta1 polymorphism is related to LVH in hypertensives. 19728040 2010
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE M<sub>3</sub>R protein level, as identified by Western blotting, was higher in mice with excessive cardiac fibrosis and in TGF-β1-induced cardiac fibrosis as well. 31849653 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE However, the role of RyR-2 in cardiac fibrosis during the development of cardiac hypertrophy remains unclear.In this study, we examined whether RyR-2 regulates TGFβ1, which is secreted from cardiomyocytes and exerts on cardiac fibrosis using cultured cardiomyocytes and cardiac fibroblasts of neonatal rats. 29162778 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 AlteredExpression disease BEFREE We also measured cardiac TGF-beta1 protein (total and active), Smad2 phosphorylation, and MMP activity after the onset of macrophage accumulation but before the onset of cardiac fibrosis. 16554301 2006
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE Transforming growth factor β 1 (TGFβ1) is as an essential inducing factor of cardiac fibrosis. 28214335 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 AlteredExpression disease BEFREE These results provide further evidence for protective effect of miR-98 overexpression on TGF-β1-induced cardiac fibrosis. 28251559 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE In CFs, preincubation with PARP1 or mTOR inhibitors all blocked TGF-β1 induced cardiac fibrosis. 29278652 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE In the present study, we investigated the inhibitory effect and mechanism of oxymatrine on cardiac fibrosis induced by TGF-β1. 30196308 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.270 Biomarker disease BEFREE Activated Mmp9 degrades extracellular matrix (ECM) and increases matrix turnover causing cardiac fibrosis that leads to heart failure. 25064116 2014
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.270 AlteredExpression disease BEFREE We hypothesize that the early induction of MMP-9 is a key regulator for modulating intracellular signaling through activation of PAR and various downstream events which are implicated in development of cardiac fibrosis in an extracellular receptor mediated kinase-1 (ERK-1) and focal adhesion kinase (FAK) dependent manner. 16202218 2005
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.270 Biomarker disease BEFREE However, it remains unclear whether miR-21 was involved in the mechanism of cardiac fibrosis with DN by target MMP-9 and ARB ameliorates cardiac fibrosis partly by inhibiting miR-21 expression. 29233785 2018