Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.010 Biomarker disease BEFREE <b>Conclusion:</b> This study demonstrates that CXCR4 pathway contributes to pathogenesis of cardiac fibrosis in dilated cardiomyopathy, and it represents a new potential therapeutic target in heart failure. 30837882 2019
Entrez Id: 3958
Gene Symbol: LGALS3
LGALS3
0.100 Biomarker disease BEFREE <b>Conclusions:</b> In conclusion, we found that galectin-3 and MMP-2 were significantly associated with global cardiac fibrosis in HFpEF patients. 30413105 2018
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.040 Biomarker disease BEFREE <b>Conclusions:</b> In conclusion, we found that galectin-3 and MMP-2 were significantly associated with global cardiac fibrosis in HFpEF patients. 30413105 2018
Entrez Id: 9734
Gene Symbol: HDAC9
HDAC9
0.010 Biomarker disease BEFREE <i>In vivo</i> study showed that HDAC inhibitor VPA blocks cardiac fibrosis, and inflammation inhibition was not involved in this process. 30093936 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.020 AlteredExpression disease BEFREE 11β-HSD1 inhibition ameliorates diabetes-induced cardiomyocyte hypertrophy and cardiac fibrosis through modulation of EGFR activity. 29221204 2017
Entrez Id: 406913
Gene Symbol: MIR126
MIR126
0.010 AlteredExpression disease BEFREE Cardiac fibrosis and inflammatory cytokine expression were also decreased after treatment with miR-126-enriched exosomes. 29241208 2017
Entrez Id: 80310
Gene Symbol: PDGFD
PDGFD
0.020 Biomarker disease BEFREE Platelet-derived growth factor D induces cardiac fibrosis and proliferation of vascular smooth muscle cells in heart-specific transgenic mice. 16224065 2005
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 PosttranslationalModification disease BEFREE Angiotensin II stimulates cardiac fibrosis and conduction heterogeneity. 19648063 2009
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE TGF-beta1 is involved in pathologic states such as cardiac hypertrophy and cardiac fibrosis; we thus postulate that the TGF-beta1 polymorphism is related to LVH in hypertensives. 19728040 2010
Entrez Id: 64123
Gene Symbol: ADGRL4
ADGRL4
0.010 Biomarker disease BEFREE ELTD1 deficiency exacerbates cardiac hypertrophy and cardiac function induced by AB-induced pressure overload by promoting both cardiomyocyte hypertrophy and cardiac fibrosis. 22606234 2012
Entrez Id: 368
Gene Symbol: ABCC6
ABCC6
0.010 Biomarker disease BEFREE Abcc6 is a previously unrecognized player in the development of stress-induced cardiac fibrosis. 25480693 2015
Entrez Id: 9360
Gene Symbol: PPIG
PPIG
0.010 Biomarker disease BEFREE CYP epoxygenase 2J2 prevents cardiac fibrosis by suppression of transmission of pro-inflammation from cardiomyocytes to macrophages. 25686540 2015
Entrez Id: 3958
Gene Symbol: LGALS3
LGALS3
0.100 Biomarker disease BEFREE Galectin-3, a β-galactoside binding lectin, has been described as a mediator of cardiac fibrosis in experimental studies and as a risk factor associated with cardiovascular events in subjects with heart failure. 26312551 2015
Entrez Id: 4921
Gene Symbol: DDR2
DDR2
0.010 Biomarker disease BEFREE DDR2 is a tyrosine kinase collagen receptor and is associated with pathological scarring of multiple organs; nevertheless, the functional role of DDR2 in the myocardium remains unclear.George et al. present evidence for the first time that Ang II induces cardiac fibrosis by enhancing DDR2 expression in cardiac fibroblasts via p38 mitogen activated protein kinase (p38 MAPK)-mediated activation of nuclear factor-κB (NF-κB). 26772530 2016
Entrez Id: 10911
Gene Symbol: UTS2
UTS2
0.020 Biomarker disease BEFREE Urotensin II (U-II/UTS2) induces cardiac fibrosis by increasing fibroblast collagen synthesis and increased U-II plasma levels have been reported in patients with atrial fibrosis. 26811505 2016
Entrez Id: 55109
Gene Symbol: AGGF1
AGGF1
0.010 Biomarker disease BEFREE AGGF1 inhibits VE-cadherin phosphorylation, increases plasma membrane VE-cadherin in ECs and in mice, blocks vascular permeability induced by ischaemia-reperfusion (IR), restores depressed cardiac function and contraction, reduces infarct sizes, cardiac fibrosis and necrosis, haemorrhages, edema, and macrophage density associated with IR. 27522498 2016
Entrez Id: 8074
Gene Symbol: FGF23
FGF23
0.040 Biomarker disease BEFREE Fibroblast growth factor 23 (FGF23) has been reported to induce left ventricular hypertrophy, but it remains unclear whether FGF23 plays a role in cardiac fibrosis. 27579618 2016
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.050 Biomarker disease BEFREE Angiotensin converting enzyme (ACE) promotes cardiac fibrosis. 27787699 2017
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
0.010 Biomarker disease BEFREE Glucocorticoid receptor alters isovolumetric contraction and restrains cardiac fibrosis. 28057868 2017
Entrez Id: 3297
Gene Symbol: HSF1
HSF1
0.010 Biomarker disease BEFREE Heat shock transcription factor 1 protects against pressure overload-induced cardiac fibrosis via Smad3. 28091697 2017
Entrez Id: 3958
Gene Symbol: LGALS3
LGALS3
0.100 Biomarker disease BEFREE Galectin-3 plays an important role in the regulation of inflammation, development of cardiac fibrosis, and remodelling. 28150280 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE Transforming growth factor β 1 (TGFβ1) is as an essential inducing factor of cardiac fibrosis. 28214335 2017
Entrez Id: 5747
Gene Symbol: PTK2
PTK2
0.010 Biomarker disease BEFREE FAK has recently received attention as a potential mediator of fibrosis, our previous study reported that pharmacological inhibition of FAK can attenuate cardiac fibrosis in post MI models. 28225063 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE TGFβ1 is a key cytokine mediating cardiac fibrosis. 28230250 2018
Entrez Id: 3958
Gene Symbol: LGALS3
LGALS3
0.100 Biomarker disease BEFREE Galectin-3 (Gal-3) is an important mediator of cardiac fibrosis, particularly in heart failure. 28525549 2018