Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3958
Gene Symbol: LGALS3
LGALS3
0.100 GeneticVariation disease BEFREE Galectin-3 gene deletion reduced cardiac fibrosis and fibrotic gene profiles and ameliorated cardiac remodeling and dysfunction. 30387702 2019
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.070 GeneticVariation disease BEFREE The aim of the study was to examine the expression of 11 microRNAs associated with cardiac fibrosis (miR-21, miR-26a, miR-26b-5p, miR-29b-3p, miR-29c-3p, miR-101a, miR-146a, miR-208a, miR-223 and miR-328) during pregnancy and to compare them with a healthy control group. 29962114 2018
Entrez Id: 6761
Gene Symbol: ST2
ST2
0.060 GeneticVariation disease BEFREE However, after injury in chronic cases activated myofibroblasts contribute to the tissue imbalance of the newer molecules associated with cardiac fibrosis, interleukin (IL-33), and suppression of tumorigenicity 2 (ST2). 31561019 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.050 GeneticVariation disease BEFREE The angiotensin-converting enzyme (ACE) deletion allele, ACE D, is associated with increased cardiac ACE activity, cardiac fibrosis, and adverse outcomes in cardiovascular disease and has been linked with failure of antiatrial fibrillation (anti-AF) drug treatment. 23876437 2013
Entrez Id: 1666
Gene Symbol: DECR1
DECR1
0.020 GeneticVariation disease BEFREE In patients receiving anthracyclines, NADPH oxidase polymorphism rs4673 protected against focal myocardial necrosis (odds ratio [OR], 0.11; 95% confidence interval [CI], 0.20-0.63) whereas rs1883112 was strongly associated with cardiac fibrosis (OR, 5.11; 95% CI, 1.59-16.43), which was present in all homozygotes. 23576480 2013
Entrez Id: 1803
Gene Symbol: DPP4
DPP4
0.020 GeneticVariation disease BEFREE Thus, IDE inhibitors, particularly when combined with DPP4 inhibitors or hypertension, could increase the risk of cardiac fibrosis. 30354710 2018
Entrez Id: 90865
Gene Symbol: IL33
IL33
0.020 GeneticVariation disease BEFREE However, after injury in chronic cases activated myofibroblasts contribute to the tissue imbalance of the newer molecules associated with cardiac fibrosis, interleukin (IL-33), and suppression of tumorigenicity 2 (ST2). 31561019 2019
Entrez Id: 27129
Gene Symbol: HSPB7
HSPB7
0.010 GeneticVariation disease BEFREE We discovered that zebrafish hspb7 mutants display mild focal cardiac fibrosis and sarcomeric abnormalities. 29331499 2018
Entrez Id: 56729
Gene Symbol: RETN
RETN
0.010 GeneticVariation disease BEFREE The -420C>G RETN polymorphism was independently associated with the degree of cardiac fibrosis, assessed by LGE, in patients with HCM. 25476756 2015
Entrez Id: 6331
Gene Symbol: SCN5A
SCN5A
0.010 GeneticVariation disease BEFREE Our findings revealed for the first time that the LQTS mutation N1325S in SCN5A causes cardiac fibrosis and contractile dysfunction in mice, possibly through cellular mechanisms involving aberrant cardiomyocyte apoptosis. 19762097 2011
Entrez Id: 5350
Gene Symbol: PLN
PLN
0.010 GeneticVariation disease BEFREE High resolution systematic digital histological quantification of cardiac fibrosis and adipose tissue in phospholamban p.Arg14del mutation associated cardiomyopathy. 24732829 2014
Entrez Id: 6016
Gene Symbol: RIT1
RIT1
0.010 GeneticVariation disease BEFREE New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis. 30898653 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE A recent study reported that deficiency of miR-378a contributes to cardiac fibrosis via TGF-β1-dependent paracrine mechanism. 27855367 2016
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE These data indicate that NE enhances cardiac fibrosis through TGF-beta1 post-receptor signaling, predominantly via the p38 MAP kinase pathway. 12154105 2002
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE TGFβ1 is a key cytokine mediating cardiac fibrosis. 28230250 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE AT‑II induces periostin expression by regulating transforming growth factor‑β1 (TGF‑β1)/Smad signaling during cardiac fibrosis. 28849131 2017
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE The axis of local cardiac endogenous Klotho-TGF-β1-Wnt signaling mediates cardiac fibrosis in human. 31520610 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE In conclusion, the results of the present study demonstrated that TGF‑β1/Smad signaling‑associated cardiac fibrosis is involved in the impairment of heart compliance and LV dysfunction in DbCM. 29138820 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE There is a close relationship between transforming growth factor-β1 mediated cardiac fibrosis and acquired arrhythmia. 27380173 2016
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease RGD Velvet antler peptide prevents pressure overload-induced cardiac fibrosis via transforming growth factor (TGF)-β1 pathway inhibition. 27108788 2016
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE Atrial fibrillation (AF) rat models and rat cardiac fibroblasts (CFs) with overexpressed or inhibited miR-10a were used to investigate the possible role of miR-10a-mediated transforming growth factor-β (TGF-β1)/Smads signaling in cardiac fibrosis and fibroblast proliferation in rats with AF. 30683806 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE Asiatic acid inhibits cardiac fibrosis throughNrf2/HO-1 and TGF-β1/Smads signaling pathways in spontaneous hypertension rats. 31254954 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE TGF-beta1 is involved in pathologic states such as cardiac hypertrophy and cardiac fibrosis; we thus postulate that the TGF-beta1 polymorphism is related to LVH in hypertensives. 19728040 2010
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE M<sub>3</sub>R protein level, as identified by Western blotting, was higher in mice with excessive cardiac fibrosis and in TGF-β1-induced cardiac fibrosis as well. 31849653 2019
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE However, the role of RyR-2 in cardiac fibrosis during the development of cardiac hypertrophy remains unclear.In this study, we examined whether RyR-2 regulates TGFβ1, which is secreted from cardiomyocytes and exerts on cardiac fibrosis using cultured cardiomyocytes and cardiac fibroblasts of neonatal rats. 29162778 2017