Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.230 Therapeutic disease RGD Effects of cilnidipine on nitric oxide and endothelin-1 expression and extracellular signal-regulated kinase in hypertensive rats. 11430925 2001
Entrez Id: 1585
Gene Symbol: CYP11B2
CYP11B2
0.010 AlteredExpression disease BEFREE In addition, CYP11B2 expression and cardiac fibrosis are found to be decreased in CHF patients on drug therapy comprising spironolactone combined with ACEIs. 11914098 2002
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.240 Biomarker disease RGD Involvement of Rho-kinase pathway for angiotensin II-induced plasminogen activator inhibitor-1 gene expression and cardiovascular remodeling in hypertensive rats. 11961044 2002
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 Biomarker disease BEFREE These data indicate that NE enhances cardiac fibrosis through TGF-beta1 post-receptor signaling, predominantly via the p38 MAP kinase pathway. 12154105 2002
Entrez Id: 4316
Gene Symbol: MMP7
MMP7
0.200 Biomarker disease RGD Fibrosis of the left atria during progression of heart failure is associated with increased matrix metalloproteinases in the rat. 12875773 2003
Entrez Id: 3816
Gene Symbol: KLK1
KLK1
0.010 Biomarker disease BEFREE Prevention of cardiac fibrosis and left ventricular dysfunction in diabetic cardiomyopathy in rats by transgenic expression of the human tissue kallikrein gene. 15117887 2004
Entrez Id: 5972
Gene Symbol: REN
REN
0.040 Biomarker disease BEFREE This article further confirms the involvement of the renin-angiotensin system in cardiac fibrosis and illustrates the supportive roles of mineralocorticoids, endothelin, and novel signaling pathways. 15218391 2004
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.240 Therapeutic disease RGD Reduced cardiac expression of plasminogen activator inhibitor 1 and transforming growth factor beta1 in obese Zucker rats by perindopril. 15604340 2005
Entrez Id: 3082
Gene Symbol: HGF
HGF
0.010 Biomarker disease BEFREE Treatment with recombinant human HGF for 3 wk suppressed cardiac fibrosis, accompanied by a decreased expression of TGF-beta1 and type I collagen. 15840903 2005
Entrez Id: 2200
Gene Symbol: FBN1
FBN1
0.200 Biomarker disease RGD Enhanced expression of fibrillin-1, a constituent of the myocardial extracellular matrix in fibrosis. 15849235 2005
Entrez Id: 7077
Gene Symbol: TIMP2
TIMP2
0.010 Biomarker disease BEFREE Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart. 16103240 2005
Entrez Id: 50507
Gene Symbol: NOX4
NOX4
0.020 AlteredExpression disease BEFREE Thus, Nox4 may play a critical role in the pathological activation of cardiac fibroblasts in cardiac fibrosis associated with human heart failure. 16179589 2005
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.270 AlteredExpression disease BEFREE We hypothesize that the early induction of MMP-9 is a key regulator for modulating intracellular signaling through activation of PAR and various downstream events which are implicated in development of cardiac fibrosis in an extracellular receptor mediated kinase-1 (ERK-1) and focal adhesion kinase (FAK) dependent manner. 16202218 2005
Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3
0.020 Biomarker disease BEFREE We hypothesize that the early induction of MMP-9 is a key regulator for modulating intracellular signaling through activation of PAR and various downstream events which are implicated in development of cardiac fibrosis in an extracellular receptor mediated kinase-1 (ERK-1) and focal adhesion kinase (FAK) dependent manner. 16202218 2005
Entrez Id: 10899
Gene Symbol: JTB
JTB
0.010 AlteredExpression disease BEFREE We hypothesize that the early induction of MMP-9 is a key regulator for modulating intracellular signaling through activation of PAR and various downstream events which are implicated in development of cardiac fibrosis in an extracellular receptor mediated kinase-1 (ERK-1) and focal adhesion kinase (FAK) dependent manner. 16202218 2005
Entrez Id: 8856
Gene Symbol: NR1I2
NR1I2
0.010 AlteredExpression disease BEFREE We hypothesize that the early induction of MMP-9 is a key regulator for modulating intracellular signaling through activation of PAR and various downstream events which are implicated in development of cardiac fibrosis in an extracellular receptor mediated kinase-1 (ERK-1) and focal adhesion kinase (FAK) dependent manner. 16202218 2005
Entrez Id: 80310
Gene Symbol: PDGFD
PDGFD
0.020 Biomarker disease BEFREE Platelet-derived growth factor D induces cardiac fibrosis and proliferation of vascular smooth muscle cells in heart-specific transgenic mice. 16224065 2005
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
0.010 Biomarker disease BEFREE The present results establish a link between 5-HTT and the development of cardiac fibrosis and valvulopathy in vivo. 16380550 2006
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.300 AlteredExpression disease BEFREE We also measured cardiac TGF-beta1 protein (total and active), Smad2 phosphorylation, and MMP activity after the onset of macrophage accumulation but before the onset of cardiac fibrosis. 16554301 2006
Entrez Id: 4087
Gene Symbol: SMAD2
SMAD2
0.050 PosttranslationalModification disease BEFREE We also measured cardiac TGF-beta1 protein (total and active), Smad2 phosphorylation, and MMP activity after the onset of macrophage accumulation but before the onset of cardiac fibrosis. 16554301 2006
Entrez Id: 5340
Gene Symbol: PLG
PLG
0.030 Biomarker disease BEFREE Our studies revealed that plasminogen is necessary for uPA-induced cardiac fibrosis and macrophage accumulation but uPAR is not. 16554301 2006
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
0.020 Biomarker disease BEFREE We hypothesized that: 1) macrophage accumulation and cardiac fibrosis in SR-uPA+/o mice are dependent on localization of uPA by the uPA receptor (uPAR); 2) activation of plasminogen by uPA and subsequent activation of transforming growth factor-beta1 (TGF-beta1) and matrix metalloproteinase (MMP)-2 and -9 by plasmin are critical pathways through which uPA-expressing macrophages accumulate in the heart and cause fibrosis; and 3) uPA-induced cardiac fibrosis can be attenuated by treatment with verapamil. 16554301 2006
Entrez Id: 118471
Gene Symbol: PRAP1
PRAP1
0.010 Biomarker disease BEFREE We hypothesized that: 1) macrophage accumulation and cardiac fibrosis in SR-uPA+/o mice are dependent on localization of uPA by the uPA receptor (uPAR); 2) activation of plasminogen by uPA and subsequent activation of transforming growth factor-beta1 (TGF-beta1) and matrix metalloproteinase (MMP)-2 and -9 by plasmin are critical pathways through which uPA-expressing macrophages accumulate in the heart and cause fibrosis; and 3) uPA-induced cardiac fibrosis can be attenuated by treatment with verapamil. 16554301 2006
Entrez Id: 2693
Gene Symbol: GHSR
GHSR
0.210 Biomarker disease RGD Cardioprotective effects of ghrelin and des-octanoyl ghrelin on myocardial injury induced by isoproterenol in rats. 16626506 2006
Entrez Id: 51738
Gene Symbol: GHRL
GHRL
0.200 ModifyingMutation disease RGD Cardioprotective effects of ghrelin and des-octanoyl ghrelin on myocardial injury induced by isoproterenol in rats. 16626506 2006