Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Inhibition of Angiotensin II-Induced Cardiac Fibrosis by Atorvastatin in Adiponectin Knockout Mice. 28474247 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Angiotensin II (Ang II), an effective component of renin-angiotensin system, plays a pivotal role in cardiac fibrosis, which may further contribute to heart failure. 30369577 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Opposite Effects of Moderate and Extreme Cx43 Deficiency in Conditional Cx43-Deficient Mice on Angiotensin II-Induced Cardiac Fibrosis. 31652649 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Endothelial-specific deletion of Ets-1 attenuates Angiotensin II-induced cardiac fibrosis via suppression of endothelial-to-mesenchymal transition. 30670148 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Next, we investigated the effects of lncRNA FAF on angiotensinogen II (Ang II)-induced cardiac fibrosis in neonatal rat CFs and explored the mechanism underlying these effects. 31708099 2020
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Endogenous Insl6 protein inhibits cardiac systolic dysfunction and cardiac fibrosis in angiotensin II- and isoproterenol-induced cardiac stress models. 29887522 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE These results suggest that macrophages when recruited into the heart and aorta from the spleen potentially contribute to angiotensin II-induced cardiac fibrosis and hypertension. 28490219 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Mice in which αv integrin is depleted in PDGFRβ<sup>+</sup> cells are protected from cardiotoxin and laceration-induced skeletal muscle fibrosis and angiotensin II-induced cardiac fibrosis. 29061963 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Echocardiographic analysis, Sirius Red staining and immunofluorescence staining were performed to investigate the function of circHIPK3 in angiotensin II (Ang II) induced cardiac fibrosis in vivo. 30967276 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE The results of histopathological analysis, as well as measurements of collagen expression and cardiac fibroblast proliferation indicated that puerarin administration significantly inhibited cardiac fibrosis induced by AB and AngII. 29928229 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Protocatechuic acid attenuates angiotensin II-induced cardiac fibrosis in cardiac fibroblasts through inhibiting the NOX4/ROS/p38 signaling pathway. 31318113 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Herein, we found that A77 1726 treatment attenuated pressure overload or angiotensin II (Ang II)-induced cardiac hypertrophy <i>in vivo</i>, as well as agonist-induced hypertrophic response of cardiomyocytes <i>in vitro</i> In addition, we showed that A77 1726 administration prevented induction of cardiac fibrosis by inhibiting cardiac fibroblast (CF) transformation into myofibroblast. 29540538 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE CD44 Deficiency in Mice Protects the Heart Against Angiotensin Ii-Induced Cardiac Fibrosis. 29470359 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Treatment with anti-IL-16 neutralizing antibody ameliorated cardiac fibrosis in the mouse model of angiotensin II-induced hypertension. 23894370 2013
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Here we describe the use a highly selective TG2 small-molecule inhibitor to test the efficacy of TG2 inhibition as an anti-fibrotic therapy for heart failure employing two different in vivo models of cardiac fibrosis: Progressively induced interstitial cardiac fibrosis by pressure overload using angiotensin II infusion: Acutely induced focal cardiac fibrosis through myocardial infarction by ligation of the left anterior descending coronary artery (AMI model). 29795262 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Inhibition of microRNA‑155 ameliorates cardiac fibrosis in the process of angiotensin II‑induced cardiac remodeling. 28944921 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Erratum to: Inhibition of Angiotensin II-Induced Cardiac Fibrosis by Atorvastatin in Adiponectin Knockout Mice. 29030734 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Steroidogenic acute regulatory protein/aldosterone synthase mediates angiotensin II-induced cardiac fibrosis and hypertrophy. 31820314 2020
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Angiotensin II (AngII) has been implicated in the development of cardiac fibrosis. 31640463 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE In conclusion, miR-29b plays a protective role in AngII-mediated cardiac remodeling and may be a therapeutic agent for cardiac fibrosis by targeting the TGF-β/Smad3 pathway. 24569834 2014
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE These results together reveal that IMM-H007 improves heart function, and alleviates AngII-induced cardiac fibrosis by regulating AMPK-TGF-β1 signaling. 31181209 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE C-reactive protein promotes cardiac fibrosis and inflammation in angiotensin II-induced hypertensive cardiac disease. 20157054 2010
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Endothelial-to-mesenchymal transition (EndMT) is a mechanism that promotes cardiac fibrosis induced by Angiotensin II (AngII). 29073623 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Here, we investigated the potential anti-myocardial fibrosis effect and mechanism of SalB on Angiotensin II (Ang II)-induced cardiac fibrosis in vitro. 30365482 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.100 Biomarker disease BEFREE Using the constitutive and dominant negative constructs of peroxisome proliferator-activated receptor γ 3-'untranslated region (UTR), data revealed that the protective mechanism was associated with restoration of peroxisome proliferator-activated receptor γ level leading to the inhibition of angiotensin II-induced cardiac fibrosis. 29114000 2017