Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.270 Biomarker disease BEFREE However, it remains unclear whether miR-21 was involved in the mechanism of cardiac fibrosis with DN by target MMP-9 and ARB ameliorates cardiac fibrosis partly by inhibiting miR-21 expression. 29233785 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.270 AlteredExpression disease BEFREE And more, rutin observably mitigated fibrosis related genes [matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9)] expression in the heart to prevent against LPS-induced cardiac fibrosis. 29743444 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.270 AlteredExpression disease BEFREE In conclusion, while STAT3 regulates matrix metalloproteinase-9 and connective tissue growth factor expression in diabetic rats with cardiac fibrosis, cryptotanshinone inhibited fibrosis to improve cardiac function by suppressing the STAT3 pathway. 28176375 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.270 Biomarker disease BEFREE Activated Mmp9 degrades extracellular matrix (ECM) and increases matrix turnover causing cardiac fibrosis that leads to heart failure. 25064116 2014
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.270 Biomarker disease RGD [Effects of xinfeng capsule on myocardial fibrosis in adjuvant arthritis rats and its mechanism research]. 23905389 2013
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.270 AlteredExpression disease BEFREE We hypothesize that the early induction of MMP-9 is a key regulator for modulating intracellular signaling through activation of PAR and various downstream events which are implicated in development of cardiac fibrosis in an extracellular receptor mediated kinase-1 (ERK-1) and focal adhesion kinase (FAK) dependent manner. 16202218 2005
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.240 Biomarker disease BEFREE In PPCM mice (due to a cardiomyocyte-specific-knockout for STAT3, CKO), cardiac PAI-1 expression was higher than in postpartum wildtype controls whereas a systemic PAI-1-knockout in CKO mice accelerated peripartum cardiac fibrosis, inflammation, heart failure, and mortality. 31711127 2019
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.240 Biomarker disease BEFREE Our findings indicate that PAI-1 protects mice from hypertension-induced cardiac fibrosis by inhibiting the generation of active Pm. 28336948 2017
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.240 Biomarker disease BEFREE PAI-1 is an essential repressor of cardiac fibrosis in mammals. 28588076 2017
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.240 Biomarker disease BEFREE Paradoxically, homozygous deficiency of PAI-1 promotes age-dependent spontaneous cardiac fibrosis, suggesting a protective role for PAI-1 in the heart. 27556351 2017
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.240 Therapeutic disease RGD Reduced cardiac expression of plasminogen activator inhibitor 1 and transforming growth factor beta1 in obese Zucker rats by perindopril. 15604340 2005
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.240 Biomarker disease RGD Involvement of Rho-kinase pathway for angiotensin II-induced plasminogen activator inhibitor-1 gene expression and cardiovascular remodeling in hypertensive rats. 11961044 2002
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.230 AlteredExpression disease BEFREE Because exposure of cardiomyocytes to TMAO increased fibronectin expression, these data suggest that linaclotide reduced the levels of TMAO and various uremic toxins and may result in not only renal, but also cardiac, fibrosis. 31411705 2020
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.230 AlteredExpression disease BEFREE Flow cytometry analysis was performed to identify cardiac fibroblasts by examining vimentin, fibronectin (FN) and α-actin expression in human CFs. qRT-PCR and western blot assays were performed to confirm the expression of miR-32-5p, DUSP1 and cardiac fibrosis relevant proteins. 31438862 2019
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.230 Biomarker disease BEFREE Endothelin-1 (ET-1) is involved in the pathogenesis of cardiac fibrosis. 28713274 2017
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.230 AlteredExpression disease BEFREE These effects of Rh2 were reversed by GSK0660 or siRNA specific for PPARδ Taken together, PPARδ activation may inhibit STAT3 activation to reduce CCN2 and fibronectin expression in diabetic rats with cardiac fibrosis. 28672855 2017
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.230 AlteredExpression disease BEFREE These observations in mice and human hearts suggest that aging-related cardiac fibrosis is, at least partially, dependent on the upregulation of ET-1. 25584774 2015
Entrez Id: 2335
Gene Symbol: FN1
FN1
0.230 Biomarker disease RGD Losartan prevents heart fibrosis induced by long-term intensive exercise in an animal model. 23383330 2013
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.230 Biomarker disease BEFREE These results provide new insights suggesting that diabetes mellitus-induced cardiac fibrosis is associated with the emergence of fibroblasts from endothelial cells and that this endothelial-to-mesenchymal transition process is stimulated by ET-1. 20497976 2010
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.230 Therapeutic disease RGD Effects of cilnidipine on nitric oxide and endothelin-1 expression and extracellular signal-regulated kinase in hypertensive rats. 11430925 2001
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.220 AlteredExpression disease BEFREE The loss of apelin increased the ratio of angiotensin-converting enzyme (ACE) to ACE2 expression in the Ang II-stressed hearts, and Ang II-induced cardiac fibrosis was markedly enhanced in apelin knockout mice. mRNA expression of pro-fibrotic genes, such as transforming growth-factor beta (TGF-β) signaling, were significantly upregulated in apelin knockout hearts. 30634441 2019
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.220 AlteredExpression disease BEFREE The effect of fluvastatin on cardiac fibrosis and angiotensin-converting enzyme-2 expression in glucose-controlled diabetic rat hearts. 28013371 2017
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.220 Therapeutic disease RGD Angiotensin-converting enzyme 2 activation protects against hypertension-induced cardiac fibrosis involving extracellular signal-regulated kinases. 21148624 2011
Entrez Id: 2697
Gene Symbol: GJA1
GJA1
0.210 Biomarker disease BEFREE Opposite Effects of Moderate and Extreme Cx43 Deficiency in Conditional Cx43-Deficient Mice on Angiotensin II-Induced Cardiac Fibrosis. 31652649 2019
Entrez Id: 2693
Gene Symbol: GHSR
GHSR
0.210 Biomarker disease BEFREE These results for the first time demonstrated that GHSR deficiency aggravated ISO-induced cardiac fibrosis, suggesting that GHSR was a potential target for the intervention of cardiac fibrosis. 31790138 2019