Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 183
Gene Symbol: AGT
AGT
0.090 Biomarker disease BEFREE Endothelial-to-mesenchymal transition (EndMT) is a mechanism that promotes cardiac fibrosis induced by Angiotensin II (AngII). 29073623 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.090 AlteredExpression disease BEFREE Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis. 25898844 2016
Entrez Id: 183
Gene Symbol: AGT
AGT
0.090 Biomarker disease BEFREE Cardiac fibrosis and cardiomyocyte hypertrophy were simulated by 100 nM angiotensin II (Ang II) in vitro. 25633415 2015
Entrez Id: 183
Gene Symbol: AGT
AGT
0.090 Biomarker disease BEFREE miR-29b as a therapeutic agent for angiotensin II-induced cardiac fibrosis by targeting TGF-β/Smad3 signaling. 24569834 2015
Entrez Id: 183
Gene Symbol: AGT
AGT
0.090 Biomarker disease BEFREE Treatment with anti-IL-16 neutralizing antibody ameliorated cardiac fibrosis in the mouse model of angiotensin II-induced hypertension. 23894370 2014
Entrez Id: 183
Gene Symbol: AGT
AGT
0.090 Biomarker disease BEFREE TNF receptor 1 signaling is critically involved in mediating angiotensin-II-induced cardiac fibrosis. 23337087 2013
Entrez Id: 183
Gene Symbol: AGT
AGT
0.090 AlteredExpression disease BEFREE In cardiac fibroblasts and rats treated with angiotensin II, berberine was found to suppress fibroblast activation, collagen synthesis, and extent of cardiac fibrosis through up-regulating relaxin. 22673230 2012
Entrez Id: 183
Gene Symbol: AGT
AGT
0.090 Biomarker disease BEFREE C-reactive protein promotes cardiac fibrosis and inflammation in angiotensin II-induced hypertensive cardiac disease. 20157054 2010
Entrez Id: 183
Gene Symbol: AGT
AGT
0.090 PosttranslationalModification disease BEFREE Angiotensin II stimulates cardiac fibrosis and conduction heterogeneity. 19648063 2010
Entrez Id: 1490
Gene Symbol: CTGF
CTGF
0.040 AlteredExpression disease BEFREE These findings demonstrate that SRF plays a key role in the modulation of cardiac fibrosis through repression of cardiomyocyte CTGF expression in a paracrine fashion. 22563064 2013
Entrez Id: 1490
Gene Symbol: CTGF
CTGF
0.040 Biomarker disease BEFREE Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor. 21382976 2011
Entrez Id: 1490
Gene Symbol: CTGF
CTGF
0.040 Biomarker disease BEFREE In an ischemia/reperfusion model CTGF-TG hearts did not differ from controls.Our data suggest that CTGF itself does not induce cardiac fibrosis. 19707545 2010
Entrez Id: 1490
Gene Symbol: CTGF
CTGF
0.040 AlteredExpression disease BEFREE Based on these findings, we propose that CTGF is an important mediator of TGF- beta signaling in the heart and abnormal expression of this gene could be used as a diagnostic marker for cardiac fibrosis. 11013125 2000
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.030 Biomarker disease BEFREE microRNA 21 (miRNA‑21) promotes the development of cardiac fibrosis, hypertrophy and heart failure. 28944900 2018
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.030 AlteredExpression disease BEFREE Osteopontin is indispensible for AP1-mediated angiotensin II-related miR-21 transcription during cardiac fibrosis. 25898844 2016
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.030 Biomarker disease BEFREE Furthermore, based on the miRNA and TF mediated regulatory network and literature survey, we proposed a pathway model for miR-21-5p, the miR-29 family and SP1 to demonstrate their potential co-regulatory mechanisms in cardiac fibrosis, apoptosis and angiogenesis. 26258537 2016
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.030 AlteredExpression disease BEFREE Endothelin-1 upregulation mediates aging-related cardiac fibrosis. 25584774 2015
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.030 Biomarker disease BEFREE TNF receptor 1 signaling is critically involved in mediating angiotensin-II-induced cardiac fibrosis. 23337087 2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.030 Biomarker disease BEFREE Compared with the wild-type mice, although Ang II infusion caused an equally high systolic blood pressure, levels of human CRP were further elevated, and cardiac remodeling was markedly exacerbated in mice that express human CRP, resulting in a significant reduction in the left ventricular ejection fraction and fractional shortening and an increase in cardiac fibrosis (collagen I and III and alpha-smooth muscle actin) and inflammation (interleukin 1beta and tumor necrosis factor-alpha). 20157054 2010
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.030 Biomarker disease BEFREE Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition. 20497976 2010
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.030 Biomarker disease BEFREE This phenotype was mediated exclusively by the Fn14 receptor, independent of tumor necrosis factor-alpha, and was associated with cardiomyocyte elongation and cardiac fibrosis but not cardiomyocyte apoptosis. 19349318 2009
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.030 Biomarker disease BEFREE These results therefore implicate ET-1 as a trophic agent in the human heart with the ability to influence the development of cardiac fibrosis. 15319532 2005
Entrez Id: 4088
Gene Symbol: SMAD3
SMAD3
0.020 Biomarker disease BEFREE Heat shock transcription factor 1 protects against pressure overload-induced cardiac fibrosis via Smad3. 28091697 2018
Entrez Id: 407021
Gene Symbol: MIR29A
MIR29A
0.020 Biomarker disease BEFREE Previous studies have shown that microRNA-29 (miR-29) can play pivotal roles in the regulation of a variety of organ fibrosis, including cardiac fibrosis, hepatic fibrosis, lung fibrosis, systemic sclerosis, and keloid. 28130757 2018
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
0.020 Biomarker disease BEFREE To investigate the effects of miR-98 on TGF-β1-induced cardiac fibrosis in human cardiac fibroblasts (HCFs), and to establish the mechanism underlying these effects, HCFs were transfected with miR-98 inhibitor or mimic, and then treated with or without TGF-β1. 28251559 2017