×
Entrez Id:
4000
Gene Symbol:
LMNA
LMNA
0.200
Biomarker
disease
MGD
Homozygous defects in LMNA, encoding lamin A/C nuclear-envelope proteins, cause autosomal recessive axonal neuropathy in human (Charcot-Marie-Tooth disorder type 2) and mouse.
11799477
2002
×
Entrez Id:
9896
Gene Symbol:
FIG4
FIG4
0.200
Biomarker
disease
MGD
Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J.
17572665
2007
×
Entrez Id:
4359
Gene Symbol:
MPZ
MPZ
0.200
Biomarker
disease
MGD
Monocyte chemoattractant protein-1 is a pathogenic component in a model for a hereditary peripheral neuropathy.
18326085
2008
×
Entrez Id:
5376
Gene Symbol:
PMP22
PMP22
0.200
Biomarker
disease
MGD
Impaired proteasome activity and accumulation of ubiquitinated substrates in a hereditary neuropathy model.
15748170
2005
×
Entrez Id:
8898
Gene Symbol:
MTMR2
MTMR2
0.200
Biomarker
disease
MGD
An animal model for Charcot-Marie-Tooth disease type 4B1.
16249189
2005
×
Entrez Id:
5376
Gene Symbol:
PMP22
PMP22
0.200
Biomarker
disease
MGD
Abnormal Schwann cell/axon interactions in the Trembler-J mouse.
9147228
1997
×
Entrez Id:
5376
Gene Symbol:
PMP22
PMP22
0.200
Biomarker
disease
MGD
Nerve conduction abnormalities in the trembler-j mouse: a model for Charcot-Marie-Tooth disease type 1A?
15363066
2004
×
Entrez Id:
81846
Gene Symbol:
SBF2
SBF2
0.200
Biomarker
disease
MGD
Mtmr13/Sbf2-deficient mice: an animal model for CMT4B2.
17855448
2007
×
Entrez Id:
5376
Gene Symbol:
PMP22
PMP22
0.200
Biomarker
disease
MGD
Oral curcumin mitigates the clinical and neuropathologic phenotype of the Trembler-J mouse: a potential therapy for inherited neuropathy.
17701891
2007
×
Entrez Id:
2617
Gene Symbol:
GARS1
GARS1
0.200
Biomarker
disease
MGD
Charcot-Marie-Tooth-linked mutant GARS is toxic to peripheral neurons independent of wild-type GARS levels.
22144914
2011
×
Entrez Id:
10397
Gene Symbol:
NDRG1
NDRG1
0.200
Biomarker
disease
MGD
Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves.
15082788
2004
×
Entrez Id:
4359
Gene Symbol:
MPZ
MPZ
0.200
Biomarker
disease
MGD
A nonsense mutation in myelin protein zero causes congenital hypomyelination neuropathy through altered P0 membrane targeting and gain of abnormal function.
30239779
2019
×
Entrez Id:
2705
Gene Symbol:
GJB1
GJB1
0.200
Biomarker
disease
MGD
Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice.
8790370
1996
×
Entrez Id:
4359
Gene Symbol:
MPZ
MPZ
0.200
Biomarker
disease
MGD
Protein zero (P0)-deficient mice show myelin degeneration in peripheral nerves characteristic of inherited human neuropathies.
7581451
1995
×
Entrez Id:
81846
Gene Symbol:
SBF2
SBF2
0.200
Biomarker
disease
MGD
Loss of the inactive myotubularin-related phosphatase Mtmr13 leads to a Charcot-Marie-Tooth 4B2-like peripheral neuropathy in mice.
18349142
2008
×
Entrez Id:
9896
Gene Symbol:
FIG4
FIG4
0.200
Biomarker
disease
MGD
Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration.
22581779
2012
×
Entrez Id:
79628
Gene Symbol:
SH3TC2
SH3TC2
0.200
Biomarker
disease
MGD
SH3TC2/KIAA1985 protein is required for proper myelination and the integrity of the node of Ranvier in the peripheral nervous system.
19805030
2009