Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.360 | Biomarker | disease | CTD_human | A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart. | 29394407 | 2018 | ||||
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0.360 | Biomarker | disease | BEFREE | This study intended to explore the effect of β-catenin on oxidative damage of DCM by establishing streptozotocin (STZ)-induced diabetic mouse model and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-treated myocardial cell model. | 28989026 | 2017 | ||||
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0.360 | Biomarker | disease | BEFREE | Our data demonstrated that canonical Wnt/β-catenin signaling was activated through nuclear accumulation of β-catenin in idiopathic dilated cardiomyopathy, ischemic heart disease, and murine desmin-related cardiomyopathy when compared with nonfailing controls and transcription factor 7-like 2 (TCF7L2) was the main β-catenin partner of the T-cell factor (TCF) family in adult hearts. | 27301468 | 2016 | ||||
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0.360 | AlteredExpression | disease | BEFREE | Furthermore, expressions of FAT1 and β-catenin were correlated with each other in DCIS and IDC (P<0.05). | 26721716 | 2016 | ||||
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0.360 | GeneticVariation | disease | BEFREE | In support of this hypothesis, we have investigated the ultrastructure of the ID in mouse hearts from control and dilated cardiomyopathy (DCM) models, the MLP-null and a cardiac-specific β-catenin mutant, cΔex3, as well as in human left ventricle from normal and DCM samples. | 23708682 | 2014 | ||||
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0.360 | Biomarker | disease | BEFREE | Association of nuclear Dvl and beta-catenin with vimentin expression suggests the importance of Wnt/beta-catenin pathway driven EMT in IDCs. | 18662704 | 2008 | ||||
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0.360 | AlteredExpression | disease | BEFREE | Analysis of tissue sections with similar rates of EC degeneration in both patient groups showed that VE-cadherin/beta-catenin expression was downregulated in DCM only (P<0.05). | 12963640 | 2003 |