Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE The detection of anti-p53 antibodies indicates that p53 is altered in amount, type or presentation in breast tumors so that it becomes immunogenic. 6292117 1982
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE We investigated the effects of the germ-line single nucleotide polymorphisms TP53 R72P (215G>C) and MDM2 SNP309 (-410T>G), and p53 protein expression in breast tumors on survival. 20021639 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE A higher prevalence of p53 mutations was found in the breast tumors of current smokers (36.5%; P = 0.02) compared with never smokers (23.6%), whereas fewer mutations were found in former smokers (16.2%; P = 0.09). 11929815 2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE High frequency of TP53 mutation in BRCA1 and sporadic basal-like carcinomas but not in BRCA1 luminal breast tumors. 19147582 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE This prognostic value may rely in part on the fact that p53 plays a role in the antiproliferative and apoptotic activities of chemotherapy regimens used to treat breast tumors. 20549698 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE The frequency of abnormalities affecting chromosome 17p and the TP53 gene was determined in 27 breast tumours from 26 female patients carrying the Icelandic BRCA2 founder mutation (999del5). 9467939 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE In summary, a new sensitive and quantitative LIA suitable for routine analysis of p53 protein in steroid receptor cytosol preparations from breast tumours has been developed to confirm the prognostic importance of p53 protein accumulation in human breast cancer. 7734292 1995
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group BEFREE We report here a rapid and robust induction of maspin expression in prostate cancer cells (LNCaP, DU145, and PC3) and breast tumor cells (MCF7) following wild type p53 expression from an adenovirus p53 expression vector (AdWTp53). p53 activates the maspin promoter by binding directly to the p53 consensus-binding site present in the maspin promoter. 10692390 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group BEFREE This work indicates that functional inactivation of the wild-type p53 protein and of the product of a gene located on 17q are essential to the development of breast neoplasms. 8137297 1994
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group BEFREE Our results in male breast tumors indicate a positive correlation between p53 mutation and p53 protein overexpression, whereas the results in female breast tumors indicate an overexpression of p53 protein even without p53 gene mutation. 8996549 1996
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE These protective effects of FR on survival and tumor incidence were paralleled by higher expression of the tumor suppressor gene p53 (wild type) and free-radical scavenging enzymes (catalase and superoxide dismutase) in breast tumors. 7604020 1995
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE This study aimed to objectively determine optimal thresholds for p53 positivity by manual and automated scoring methods using whole tissue sections from the Carolina Breast Cancer Study. p53-immunostained slides were available for 564 breast tumors previously assayed for TP53 mutations. 26200835 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE Furthermore, Notch-induced transcriptomes from p53 wild-type and -mutated breast tumor cell lines differed extensively, and for a subset of genes upregulated by Notch in a p53-mutant cell line, this upregulation was reduced by wild-type p53. 23178494 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE The literature suggests that it is now appropriate to start assessing the p53 gene status of breast tumors for prognosis. 7664481 1995
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group BEFREE Here we describe the analysis of BRCA1, PTEN, and p53 at the single cell level in 55 BRCA1-associated breast tumors and computational methods to predict the relative temporal order of somatic events, on the basis of the frequency of cells with single or combined alterations. 22628410 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE Examination of all 49 breast tumors revealed a 61% frequency of deletion at or near the p53 locus. 2052583 1991
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE The tumour-suppressor gene TP53 is frequently mutated in breast tumours, and the majority of the mutations are clustered within the core domain, the region involved in DNA binding. 9569050 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group BEFREE Nuclear expression of CHEK1 was present in 61% of breast tumours and was associated with tumour size, triple-negative cancer, basal-like phenotype, the epithelial-mesenchymal transition, p53 over-expression, DNA homologous repair pathway dysfunction, and poor prognosis. 29075961 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE Mutations in the p53 tumor suppressor gene are frequent in breast tumors but the implication of p53 mutations in breast cancer development remains poorly understood. 15246568 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE 1-kb segment of the p53 tumor suppressor gene (54.5% G+C) containing exons 5-9, including the intervening introns, was screened in a blinded analysis of 48 samples from human breast tumors containing known wild-type or mutant p53 genes. 10425040 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE Household income is associated with the p53 mutation frequency in human breast tumors. 23469190 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE Expression of the ataxia telangiectasia (ATM) and p53 proteins was immunohistochemically evaluated in 18 benign and malignant myoepithelial tumours of the breast. 15509680 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 Biomarker group BEFREE Our strategy involved using a retrovirus containing a p53-regulated lacZ reporter gene that was introduced into colon and breast tumor cell lines to determine p53 status. 12725531 2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 AlteredExpression group BEFREE There was an excellent correlation between the breast tumor cell lines and their corresponding tumor tissues for morphological features (100%); presence of aneuploidy (87%); immunohistochemical expression of estrogen receptors (87%), progesterone receptors (73%), and HER2/neu (93%) and p53 proteins (100%); allelic loss at all of the chromosomal regions analyzed (82-100% concordance); and TP53 gene mutations (75%). 9865903 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.700 GeneticVariation group BEFREE Estrogen receptor negative (ER(-ve)) and p53 mutant breast tumors are highly aggressive and have fewer treatment options. 22027149 2011