×
Entrez Id:
3952
Gene Symbol:
LEP
LEP
0.400
Biomarker
group
BEFREE
Blocking FAO and/or leptin re-sensitizes them to chemotherapy and inhibits BCSCs in mouse breast tumors in vivo.
29249690
2018
×
Entrez Id:
3952
Gene Symbol:
LEP
LEP
0.400
AlteredExpression
group
BEFREE
Accordingly, HNK treatment inhibited breast tumor growth in diet-induced-obese mouse model (exhibiting high leptin levels) in a manner associated with activation of miR-34a and inhibition of MTA1-β-catenin.
26036628
2015
×
Entrez Id:
3952
Gene Symbol:
LEP
LEP
0.400
AlteredExpression
group
BEFREE
Leptin , an adipokine is produced in high levels in obese individuals, and its receptor is overexpressed in breast tumors and lymph node metastases.
22200873
2012
×
Entrez Id:
3952
Gene Symbol:
LEP
LEP
0.400
AlteredExpression
group
BEFREE
Perturbations in the adipocytokine profile, especially higher levels of leptin , are a major cause of breast tumor progression and metastasis; the underlying mechanisms, however, are not well understood.
22270359
2012
×
Entrez Id:
3952
Gene Symbol:
LEP
LEP
0.400
Biomarker
group
BEFREE
Importantly, leptin increased breast tumor growth in nude mice.
21555376
2011
×
Entrez Id:
3952
Gene Symbol:
LEP
LEP
0.400
Biomarker
group
CTD_human
Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer.
21353530
2011
×
Entrez Id:
3952
Gene Symbol:
LEP
LEP
0.400
AlteredExpression
group
BEFREE
Leptin can up-regulate the expression of ERalpha and down-regulate the expression of the ERbeta in human breast tumor .
20193256
2010
×
Entrez Id:
3952
Gene Symbol:
LEP
LEP
0.400
AlteredExpression
group
BEFREE
Leptin is overexpressed in human breast tumors and is produced by breast cancer cells in response to obesity-related stimuli.
19408304
2009
×
Entrez Id:
3952
Gene Symbol:
LEP
LEP
0.400
Biomarker
group
BEFREE
There is evidence that adipokines such as leptin and adiponectin may influence breast tumor development.
19723917
2009
×
Entrez Id:
3952
Gene Symbol:
LEP
LEP
0.400
Biomarker
group
BEFREE
Evidence indicates that leptin plays an important role in mammary tumor formation; however, the mechanisms involved are poorly understood.
18715880
2008
×
Entrez Id:
3952
Gene Symbol:
LEP
LEP
0.400
AlteredExpression
group
LHGDN
Mechanism of leptin expression in breast cancer cells: role of hypoxia-inducible factor-1alpha.
17653093
2008
×
Entrez Id:
3952
Gene Symbol:
LEP
LEP
0.400
AlteredExpression
group
LHGDN
leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3.
17344214
2007
×
Entrez Id:
3952
Gene Symbol:
LEP
LEP
0.400
Biomarker
group
BEFREE
Together, these results provide further evidence suggesting leptin is a MT growth-promoting factor.
16825198
2006
×
Entrez Id:
3952
Gene Symbol:
LEP
LEP
0.400
Biomarker
group
BEFREE
The association between both intratumoral Lep-R(L) and Lep-R(S) mRNA high tumors and a poor prognosis in the presence of high serum leptin or high intratumoral leptin mRNA levels seems to suggest that the leptin and Lep-R(L)/Lep-R(S) pathways are implicated in the growth stimulation of breast tumors .
16206269
2006
×
Entrez Id:
3952
Gene Symbol:
LEP
LEP
0.400
AlteredExpression
group
LHGDN
Messenger RNA expression of leptin and leptin receptors and their prognostic value in 322 human primary breast cancers.
16609020
2006
×
Entrez Id:
3952
Gene Symbol:
LEP
LEP
0.400
AlteredExpression
group
LHGDN
Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli.
16533767
2006
×
Entrez Id:
3952
Gene Symbol:
LEP
LEP
0.400
AlteredExpression
group
LHGDN
Leptin: a proliferative factor for breast cancer? Study on human ductal carcinoma.
16009333
2005
×
Entrez Id:
3952
Gene Symbol:
LEP
LEP
0.400
Biomarker
group
LHGDN
Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer.
15240518
2004
×
Entrez Id:
3952
Gene Symbol:
LEP
LEP
0.400
AlteredExpression
group
LHGDN
Serum leptin, prolactin and vascular endothelial growth factor (VEGF) levels in patients with breast cancer.
12687277
2003
×
Entrez Id:
3952
Gene Symbol:
LEP
LEP
0.400
AlteredExpression
group
LHGDN
Leptin enhances, via AP-1, expression of aromatase in the MCF-7 cell line.
12734209
2003
×
Entrez Id:
3952
Gene Symbol:
LEP
LEP
0.400
Biomarker
group
LHGDN
Leptin mediates a proliferative response in human MCF7 breast cancer cells.
12054648
2002
×
Entrez Id:
3952
Gene Symbol:
LEP
LEP
0.400
Biomarker
group
BEFREE
Leptin protein was identified in T47D breast cancer cells by indirect immunofluorescent staining and in samples of the same breast tumors used for Northern studies by enzyme-linked immunosorbent assays (ELISA).
10364481
1999