×
Entrez Id:
857
Gene Symbol:
CAV1
CAV1
0.400
Biomarker
group
BEFREE
One factor, which may drive ongoing matrix synthesis in breast tumors, is the loss of stromal caveolin-1 (cav-1 ), a scaffolding protein of caveolae, which has been linked to breast tumor aggressiveness.
28187162
2017
×
Entrez Id:
857
Gene Symbol:
CAV1
CAV1
0.400
PosttranslationalModification
group
BEFREE
Cav1 CGI shore methylation was also observed in human breast tumors , and overall survival rates of breast cancer patients lacking estrogen receptor α (ERα) negatively correlated with Cav1 expression.
23128390
2013
×
Entrez Id:
857
Gene Symbol:
CAV1
CAV1
0.400
Biomarker
group
CTD_human
Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization.
21501481
2011
×
Entrez Id:
857
Gene Symbol:
CAV1
CAV1
0.400
Biomarker
group
CTD_human
Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling.
20562527
2010
×
Entrez Id:
857
Gene Symbol:
CAV1
CAV1
0.400
Biomarker
group
CTD_human
Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance.
19288272
2010
×
Entrez Id:
857
Gene Symbol:
CAV1
CAV1
0.400
Biomarker
group
LHGDN
Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts.
19234134
2009
×
Entrez Id:
857
Gene Symbol:
CAV1
CAV1
0.400
Biomarker
group
CTD_human
Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts.
19234134
2009
×
Entrez Id:
857
Gene Symbol:
CAV1
CAV1
0.400
AlteredExpression
group
BEFREE
Importantly, in vivo experiments employing xenograft tumor models demonstrated that expression of caveolin-1 results in significant growth inhibition of breast tumors .
18778685
2008
×
Entrez Id:
857
Gene Symbol:
CAV1
CAV1
0.400
GeneticVariation
group
LHGDN
Caveolae/caveolin-1 are important modulators of store-operated calcium entry in Hs578/T breast cancer cells.
18296864
2008
×
Entrez Id:
857
Gene Symbol:
CAV1
CAV1
0.400
PosttranslationalModification
group
LHGDN
Caveolin-1 tyrosine phosphorylation enhances paclitaxel-mediated cytotoxicity.
17190831
2007
×
Entrez Id:
857
Gene Symbol:
CAV1
CAV1
0.400
AlteredExpression
group
LHGDN
Abrogation of p53 by its antisense in MCF-7 breast carcinoma cells increases cyclin D1 via activation of Akt and promotion of cell proliferation.
17935714
2007
×
Entrez Id:
857
Gene Symbol:
CAV1
CAV1
0.400
Biomarker
group
LHGDN
Caveolin-1 expression is associated with a basal-like phenotype in sporadic and hereditary breast cancer.
16541313
2006
×
Entrez Id:
857
Gene Symbol:
CAV1
CAV1
0.400
AlteredExpression
group
LHGDN
Albumin-bound paclitaxel, ABI-007 may show better efficacy than paclitaxel in basal-like breast cancers: association between caveolin-1 expression and ABI-007.
16897435
2006
×
Entrez Id:
857
Gene Symbol:
CAV1
CAV1
0.400
AlteredExpression
group
LHGDN
Overexpression of caveolin-1 and -2 in cell lines and in human samples of inflammatory breast cancer.
16244790
2006
×
Entrez Id:
857
Gene Symbol:
CAV1
CAV1
0.400
AlteredExpression
group
LHGDN
Caveolin-1 inhibits cell detachment-induced p53 activation and anoikis by upregulation of insulin-like growth factor-I receptors and signaling.
15592498
2005
×
Entrez Id:
857
Gene Symbol:
CAV1
CAV1
0.400
PosttranslationalModification
group
LHGDN
Mutational, epigenetic and expressional analyses of caveolin-1 gene in breast cancers.
15375584
2004
×
Entrez Id:
857
Gene Symbol:
CAV1
CAV1
0.400
Biomarker
group
BEFREE
This study provides the first functional evidence that caveolin-1 regulates primary breast tumor growth and spontaneous metastasis of breast cancer.
15334058
2004
×
Entrez Id:
857
Gene Symbol:
CAV1
CAV1
0.400
Biomarker
group
LHGDN
This study provides the first functional evidence that caveolin-1 regulates primary breast tumor growth and spontaneous metastasis of breast cancer.
15334058
2004
×
Entrez Id:
857
Gene Symbol:
CAV1
CAV1
0.400
Biomarker
group
BEFREE
We investigated the function of caveolin-1 protein in breast tumors .
14506991
2003
×
Entrez Id:
857
Gene Symbol:
CAV1
CAV1
0.400
Biomarker
group
BEFREE
Together our data refute a role for CAVEOLIN-1 as a breast tumour suppressor gene in vivo.
10086342
1999