We speculate that according to physical models closing of the tubular tracheal network provokes initial increase of the internal hydrostatic pressure necessary for gas generation through cavitation when the pressure is subsequently decreased.
Such a hybrid nanoreactor exhibited sensitive catalytic activity toward H<sub>2</sub>O<sub>2</sub>, facilitating the continuous O<sub>2</sub> gas generation in a relatively mild manner even if incubated with 10 μM H<sub>2</sub>O<sub>2</sub>, which finally led to enhanced ablation in the tissue-mimicking PAA gel model after HIFU exposure mainly resulting from intensified cavitation effect.