Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 57680
Gene Symbol: CHD8
CHD8 		0.800 Biomarker disease CLINGEN Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-β-catenin signaling pathway. 22083958 2012
Entrez Id: 57680
Gene Symbol: CHD8
CHD8 		0.800 Biomarker disease CLINGEN Our findings indicate that CHD8 disruptions define a distinct ASD subtype and reveal unexpected comorbidities between brain development and enteric innervation. 24998929 2014
Entrez Id: 57680
Gene Symbol: CHD8
CHD8 		0.800 Biomarker disease CLINGEN Mutations in chromodomain helicase DNA-binding domain 8 (CHD8) have been identified in independent genotyping studies of autism spectrum disorder. 26789910 2016
Entrez Id: 57680
Gene Symbol: CHD8
CHD8 		0.800 Biomarker disease CLINGEN Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. 22495309 2012
Entrez Id: 57680
Gene Symbol: CHD8
CHD8 		0.800 Biomarker disease CLINGEN De novo genic mutations among a Chinese autism spectrum disorder cohort. 27824329 2016
Entrez Id: 57680
Gene Symbol: CHD8
CHD8 		0.800 Biomarker disease CLINGEN REST activation was also observed in the brains of humans with ASD, and CHD8 was found to interact physically with REST in the mouse brain. 27602517 2016
Entrez Id: 9379
Gene Symbol: NRXN2
NRXN2 		0.740 Biomarker disease GENOMICS_ENGLAND A de novo 921 Kb microdeletion at 11q13.1 including neurexin 2 in a boy with developmental delay, deficits in speech and language without autistic behaviors. 29654904 2018
Entrez Id: 54413
Gene Symbol: NLGN3
NLGN3 		0.600 Biomarker disease GENOMICS_ENGLAND
Entrez Id: 9369
Gene Symbol: NRXN3
NRXN3 		0.330 Biomarker disease GENOMICS_ENGLAND A rare exonic NRXN3 deletion segregating with neurodevelopmental and neuropsychiatric conditions in a three-generation Chinese family. 30076746 2018
Entrez Id: 9320
Gene Symbol: TRIP12
TRIP12 		0.320 Biomarker disease GENOMICS_ENGLAND CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors. 25294932 2014
Entrez Id: 2742
Gene Symbol: GLRA2
GLRA2 		0.310 Biomarker disease GENOMICS_ENGLAND α2-glycine receptors modulate adult hippocampal neurogenesis and spatial memory. 29057625 2017
Entrez Id: 23040
Gene Symbol: MYT1L
MYT1L 		0.300 Biomarker disease GENOMICS_ENGLAND CHD8 regulates neurodevelopmental pathways associated with autism spectrum disorder in neural progenitors. 25294932 2014
Entrez Id: 55879
Gene Symbol: GABRQ
GABRQ 		0.300 Biomarker disease GENOMICS_ENGLAND Targeted Next-Generation Sequencing Analysis of 1,000 Individuals with Intellectual Disability. 26350204 2015
Entrez Id: 54413
Gene Symbol: NLGN3
NLGN3 		0.600 Biomarker disease RGD FMRP, a protein with numerous proposed functions including regulation of mRNA and synaptic protein synthesis, and NLGN3, a member of the neuroligin synaptic cell-adhesion protein family, have been implicated in human ASD. 24773431 2014
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1 		0.600 Biomarker disease RGD The presence of pronounced impairments in several domains in NRXN1α KO rats clearly suggests that nonsocial cognitive deficits can also be measured in an animal model of ASD. 25420124 2015
Entrez Id: 7249
Gene Symbol: TSC2
TSC2 		0.380 Biomarker disease RGD Epilepsy and Tsc2 haploinsufficiency lead to autistic-like social deficit behaviors in rats. 20927644 2011
Entrez Id: 2332
Gene Symbol: FMR1
FMR1 		0.300 Biomarker disease RGD FMRP, a protein with numerous proposed functions including regulation of mRNA and synaptic protein synthesis, and NLGN3, a member of the neuroligin synaptic cell-adhesion protein family, have been implicated in human ASD. 24773431 2014
Entrez Id: 57680
Gene Symbol: CHD8
CHD8 		0.800 Biomarker disease MGD
Entrez Id: 9379
Gene Symbol: NRXN2
NRXN2 		0.740 Biomarker disease MGD
Entrez Id: 26047
Gene Symbol: CNTNAP2
CNTNAP2 		0.700 Biomarker disease MGD
Entrez Id: 85358
Gene Symbol: SHANK3
SHANK3 		0.700 Biomarker disease MGD
Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1 		0.600 Biomarker disease MGD
Entrez Id: 54413
Gene Symbol: NLGN3
NLGN3 		0.600 Biomarker disease MGD
Entrez Id: 2020
Gene Symbol: EN2
EN2 		0.590 Biomarker disease MGD
Entrez Id: 1742
Gene Symbol: DLG4
DLG4 		0.550 Biomarker disease MGD