Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.400 Biomarker disease BEFREE RELN is considered an important modulator for ASD, since there are several polymorphisms in this gene linked to the disease, and since lower levels of RELN have been reported in brains of ASD patients. 30668980 2019
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.400 GeneticVariation disease BEFREE A significant genetic association between SNP2 (located in intron 59 of RELN) and ASD was observed, and the log-additive model was accepted as the best inheritance model fitting this data (OR: 0.72, 95% CI: 0.54-0.97, P = 0.03). 17955477 2008
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.400 GeneticVariation disease BEFREE Genetic studies of human patients have demonstrated association between the RELN locus and autism spectrum disorder, schizophrenia, bipolar disorder, and Alzheimer's disease. 31607872 2019
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.400 Biomarker disease BEFREE These findings suggest that both a deficiency in Reelin signaling and pathologic impairment of Reelin secretion may contribute to ASD risk. 28419454 2017
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.400 GeneticVariation disease BEFREE Genetic analysis of reelin gene (RELN) SNPs: no association with autism spectrum disorder in the Indian population. 18597938 2008
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.400 Biomarker disease BEFREE Reelin gene (RELN), which plays a crucial role in the migration and positioning of neurons during brain development, has been strongly posed as a candidate gene for ASD. 24453138 2014
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.400 Biomarker disease CTD_human Disrupted brain thyroid hormone homeostasis and altered thyroid hormone-dependent brain gene expression in autism spectrum disorders. 24781735 2014
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.400 Biomarker disease BEFREE The reelin gene is a strong candidate in the etiology of several psychiatric disorders such as schizophrenia, major depression, bipolar disorders, and autism spectrum disorders. 28127276 2016
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.400 Biomarker disease CTD_human Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases. 28191889 2017
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.400 GeneticVariation disease BEFREE This study aimed to provide additional evidence for the association between two SNPs of RELN (i.e., rs736707, rs2229864) and ASD risk, as well as the relationship between RELN gene and symptom-based and developmental deficits of ASD patients in Chinese Han children and adolescents. 29753726 2018
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.400 AlteredExpression disease BEFREE Our data demonstrate that RELN, GAD1, and several other genes selectively expressed in GABAergic neurons, are down-regulated in post-mortem ASD FC. 28229923 2017
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.400 Biomarker disease BEFREE Moreover, we detected a significant increase in TET1 expression and an enrichment in the level of 5-hmC, but not 5-mC, at the promoters of GAD1 and RELN in ASD when compared with CON. 24448211 2014
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.400 Biomarker disease BEFREE Taken together, our findings point to an abnormal interplay between Reelin-DAB1 and mTORC1 networks in nonsyndromic ASD. 29969175 2018
Entrez Id: 5649
Gene Symbol: RELN
RELN
0.400 GeneticVariation disease BEFREE Reelin gene alleles and susceptibility to autism spectrum disorders. 12399956 2002