Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 AlteredExpression disease BEFREE The current project aimed at comparison of transcript levels of brain derived neurotrophic factor (BDNF), beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), and their natural occurring antisenses in the peripheral blood of ASD individuals (n = 50, male/female = 38/12, age (mean ± standard deviation (SD)): 6 ± 1.4, age range: 3-8) and matched healthy persons (n = 50, male/female = 37/13, age (mean ± SD): 6 ± 1.74, age range: 3-8). 31760580 2020
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker disease BEFREE We performed a nested case-control study of the relation between blood levels of neuro-developmental (S100B, BDNF, and VEGF-A) and inflammatory (MCP-1, TARC, IL-8, IL-18, CRP, and IgA) biomarkers in newborns, and later development of autism spectrum disorders (ASD, N = 751), attention deficit hyperactivity disorders (ADHD, N = 801), schizophrenia (N = 1969), affective (N = 641) or bipolar disorders (N = 641). 31591381 2019
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker disease BEFREE Dysregulation of neurotrophins such as BDNF and their signaling pathways have been implicated in ASD. 29691724 2018
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker disease BEFREE Increased BDNF production and changes in the metabolism of tryptophan are associated with many ASD characteristics, showing particularly strong associations with childhood autism and Intellectual and Developmental Disabilities. 30033880 2018
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 AlteredExpression disease BEFREE Having a child with ASD raises the BDNF levels in parents comparing to controls. 29532458 2018
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker disease BEFREE As most of this work has investigated the role of brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1) in ASD formation, we focus on these two molecules in this review. 28551754 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker disease BEFREE And, the BDNF genotyping results showed that there was no difference between the ASD cases and the control. 26820673 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker disease BEFREE Sexually Dimorphic Epigenetic Regulation of Brain-Derived Neurotrophic Factor in Fetal Brain in the Valproic Acid Model of Autism Spectrum Disorder. 29073621 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 AlteredExpression disease BEFREE Meanwhile, in ASD group, the average escape latency and the frequency of crossing plates were decreased, the apoptotic index (AI) detected by TUNEL assay was increased, and the expression of brain-derived neurotrophic factor (BDNF) and B-cell lymphoma 2 (Bcl-2) analyzed was decreased with great difference compared with normal group (<i>P</i><0.01). 28360521 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker disease BEFREE We find that translation of dyrk1a, a Down syndrome- and autism spectrum disorders-related gene, is dependent on Mena, both in steady-state conditions and upon BDNF stimulation. 28735747 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker disease BEFREE The present meta-analysis study led to conclusion that BDNF might play role in autism initiation/ propagation and therefore it can be considered as a possible biomarker of ASD. 28138831 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker disease BEFREE In this concise review, we summarize the current evidence that supports the role of brain-derived neurotrophic factor, insulin-like growth factor 2, hepatocyte growth factor (HGF), glial-derived neurotrophic factor, nerve growth factor, neurotrophins 3 and 4, and epidermal growth factor in the pathogenesis of ADHD and ASD. 28751869 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 AlteredExpression disease BEFREE Aberrant cognitive phenotypes and altered hippocampal BDNF expression related to epigenetic modifications in mice lacking the post-synaptic scaffolding protein SHANK1: Implications for autism spectrum disorder. 28500650 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker disease BEFREE Emerging promise of amitriptyline in ASD is discussed, together with promising BDNF effects of loxapine and amitriptyline. 28335658 2017
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker disease BEFREE This meta-analysis suggests that peripheral BDNF levels are a potential biomarker of ASD. 27506602 2016
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 GeneticVariation disease BEFREE Neither BDNF Val66Met genotype nor plasma BDNF was significantly associated with the presence or severity of ASD or PTSD. 26999419 2016
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker disease BEFREE An increase in the size of the patient cohort seems necessary to ascertain whether decreased IL-18 content in the sera can become a predictive biomarker of ASD and whether its measure, in combination with other markers (e.g., increased levels of brain-derived neurotrophic factor (BDNF)), may be included in a diagnostic panel. 26728085 2016
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker disease BEFREE Discovery of the lncRNAs of SHANK2-AS and BDNF-AS, the natural antisense of genes SHANK2 and BDNF, respectively, indicates that in addition to gene mutations, deregulation of lncRNAs on ASD-causing gene loci presents a new approach for exploring possible epigenetic mechanisms underlying ASD. 26485544 2015
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 AlteredExpression disease BEFREE Neurotrophin blood-based gene expression and social cognition analysis in patients with autism spectrum disorder. 25535174 2015
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 AlteredExpression disease BEFREE Lack of microglial phagocytosis and decreased levels of BDNF appear to distinguish Rett syndrome from ASDs, in which there is instead microglia activation and/or proliferation and possibly defective BDNF signaling. 25669997 2015
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker disease CTD_human Disrupted brain thyroid hormone homeostasis and altered thyroid hormone-dependent brain gene expression in autism spectrum disorders. 24781735 2014
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker disease BEFREE Using diagnostic measures and clinical judgement, 3 subjects (2 BDNF+/- and 1 BDNF+/+) in the WAGR group (10.7%) were classified with autism spectrum disorder. 23517654 2014
Entrez Id: 627
Gene Symbol: BDNF
BDNF
0.400 Biomarker disease BEFREE BDNF and COMT may be biomarkers for phenotypic variation in ASD, but these preliminary findings remain tentative pending replication with larger, independent samples. 19582565 2009