The DOCA-salt rats had significantly increased cortical ADC and T2 values at weeks 6 and 8 (1.778 ± 0.051 × 10<sup>-3</sup> mm<sup>2</sup>/s vs 1.872 ± 0.058-1.917 ± 0.066 × 10<sup>-3</sup> mm<sup>2</sup>/s; 93.7 ± 4.9 ms vs 98.0 ± 2.9-100.7 ± 4.0 ms, respectively, all P < 0.05), consistent with excessively fluid-filled microcysts (aquaporin-2+).