Gene: TIGIT ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 201633
Gene Symbol: TIGIT
TIGIT 		0.030 AlteredExpression phenotype BEFREE We previously demonstrated that the Fap2 outer-surface protein of <i>F. nucleatum</i> binds and activates the human inhibitory receptor TIGIT which is expressed by T and Natural Killer (NK) cells, and inhibits anti-tumor immunity.Here we show that <i>F. nucleatum</i> also binds and activates the human inhibitory receptor CEACAM1 leading to inhibition of T and NK cells activities. 31069151 2019
Entrez Id: 201633
Gene Symbol: TIGIT
TIGIT 		0.030 Biomarker phenotype BEFREE Blockade of TIGIT prevented NK cell exhaustion and promoted NK cell-dependent tumor immunity in several tumor-bearing mouse models. 29915296 2018
Entrez Id: 201633
Gene Symbol: TIGIT
TIGIT 		0.030 Biomarker phenotype BEFREE Deficiency of host CD96 and PD-1 or TIGIT enhances tumor immunity without significantly compromising immune homeostasis. 29900061 2018