Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.070 Biomarker phenotype BEFREE These results with analysis of vaccine-elicited CD8 + T cells for tumor-specific killing and regulatory cell marker expression, add further support to our premise that CD8+ IL-10 + T cells elicited by D52 tumor-self protein vaccine contribute to the suppression of a memory CTL responses and durable tumor immunity. 31769704 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.070 Biomarker phenotype BEFREE Our results reveal previously unappreciated cooperative roles for T<sub>reg</sub> cell-derived IL-10 and IL-35 in promoting BLIMP1-dependent exhaustion of CD8<sup>+</sup> TILs that limits effective anti-tumor immunity. 30936494 2019
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.070 Biomarker phenotype BEFREE Interleukin-10 (IL-10) induces an immunosuppressive microenvironment including M2 macrophages, inhibiting anti-tumor immunity. 29100307 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.070 Biomarker phenotype BEFREE Interleukin 10 is a cytokine with controversial roles in CD8<sup>+</sup> T cell-mediated anti-tumor immunity. 28488547 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.070 Biomarker phenotype BEFREE Lack of IL-10 allows induction of pro-inflammatory cytokines and hinders anti-tumor immunity, thereby favoring tumor growth. 25056661 2014
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.070 AlteredExpression phenotype BEFREE This suggests that intraperitoneally administered Th1-like cells, producing elevated levels of IL-10, may require and/or induce differential levels of distinct systemic TReg subpopulations that influence, in part, long-term tumor immunity and enhanced memory/effector CD4-mediated therapeutic potentials. 22083345 2012
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.070 Biomarker phenotype BEFREE Together, our results demonstrate an antagonistic effect of IL-10 with respect to GM-CSF-induced DC accumulation and tumor immunity and suggest a new mechanism by which tumors escape immune recognition: namely by preventing APC from obtaining access to tumor Ags. 9218594 1997