We previously demonstrated that the Fap2 outer-surface protein of <i>F. nucleatum</i> binds and activates the human inhibitory receptor TIGIT which is expressed by T and Natural Killer (NK) cells, and inhibits anti-tumor immunity.Here we show that <i>F. nucleatum</i> also binds and activates the human inhibitory receptor CEACAM1 leading to inhibition of T and NK cells activities.