Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 811
Gene Symbol: CALR
CALR
0.060 Biomarker phenotype BEFREE The cell surface translocation of calreticulin (ecto-CRT) serves as an "eat me" signal for phagocytosis of dying cells, which plays a pivotal role in activating anti-tumor immunity. 31807524 2019
Entrez Id: 811
Gene Symbol: CALR
CALR
0.060 Biomarker phenotype BEFREE Therapy-induced presentation of cell surface calreticulin (CRT) is a pro-phagocytic immunogen beneficial for invoking anti-tumor immunity. 31192123 2019
Entrez Id: 811
Gene Symbol: CALR
CALR
0.060 Biomarker phenotype BEFREE Calreticulin (CRT), a multifunctional Ca<sup>2+</sup>-binding glycoprotein mainly located in the endoplasmic reticulum, is a tumor-associated antigen that has been shown to play protective roles in angiogenesis suppression and anti-tumor immunity. 29075268 2017
Entrez Id: 811
Gene Symbol: CALR
CALR
0.060 Biomarker phenotype BEFREE However, it remains unclear whether the effect of CRT on cancer cell phagocytosis is alone sufficient to affect tumor immunity. 28507789 2017
Entrez Id: 811
Gene Symbol: CALR
CALR
0.060 AlteredExpression phenotype BEFREE Taken together, these results suggest that local CIRT combined with IV DCs augments an immunogenicity of the tumor cells by ecto-calreticulin expression and the maturation of DCs to stimulate anti-tumor immunity to decrease lung metastases. 28339788 2017
Entrez Id: 811
Gene Symbol: CALR
CALR
0.060 Biomarker phenotype BEFREE To enhance the immunogenecity of CEA, we developed a fusion gene (CRT-TAT-DeltaCEA) of the TAT protein transduction domain (PTD) and calreticulin (CRT) with human CEA devoid of its signal sequences (DeltaCEA) and evaluated anti-tumor immunity using RNA-pulsed dendritic cell (DC) vaccination. 18812201 2008