Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | phenotype | BEFREE | We conclude that the Tim-3-galectin-9 pathway is operated by a wide range of human cancer cells and is possibly involved in prevention of anti-tumor immunity. | 31354733 | 2019 | ||||
|
0.080 | AlteredExpression | phenotype | BEFREE | This paper focuses on the TIM-3 regulation of immune cells, and its expression and mechanism in patients with liver, gastric and prostate cancers in order to explore its regulatory mechanism in tumor immunity and provide new ideas and targets for tumor immunotherapy. | 30509105 | 2019 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | A blockade of T cell immunoglobulin and mucin-domain containing-3 (Tim-3) immune checkpoint had a negligible effect on anti-tumor immunity and TAMs repolarization. | 30469401 | 2018 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | T cell immunoglobulin and mucin domain 3 (TIM-3) has been shown to mediate immune tolerance in mouse models of infectious diseases, alloimmunity, autoimmunity, and tumor Immunity. | 28300768 | 2017 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | A TIM-3 Oligonucleotide Aptamer Enhances T Cell Functions and Potentiates Tumor Immunity in Mice. | 28800954 | 2017 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | Tim-3 has gained prominence as a potential candidate for cancer immunotherapy, where it has been shown that in vivo blockade of Tim-3 with other check-point inhibitors enhances anti-tumor immunity and suppresses tumor growth in several preclinical tumor models. | 28258697 | 2017 | ||||
|
0.080 | AlteredExpression | phenotype | BEFREE | However, the nature of Tim-3 expression in the tumor cell and the mechanism by which it inhibits anti-tumor immunity are unclear. | 23335978 | 2013 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | Emerging Tim-3 functions in antimicrobial and tumor immunity. | 21697013 | 2011 |