Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Long Noncoding RNA PURPL Suppresses Basal p53 Levels and Promotes Tumorigenicity in Colorectal Cancer. 28877474 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Critical Role of p53 and K-ras in the Diagnosis of Early Colorectal Cancer: a One-year, Single-center Analysis. 29104470 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Expression of ERCC1, RRM1, TUBB3 in correlation with apoptosis repressor ARC, DNA mismatch repair proteins and p53 in liver metastasis of colorectal cancer. 28949378 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE AA-NAT, MT1 and MT2 Correlates with Cancer Stem-Like Cell Markers in Colorectal Cancer: Study of the Influence of Stage and p53 Status of Tumors. 28604612 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Our research found that PDT suppressed CRC cell viability, reduced the tumor size and prolonged the survival time, all of which could be attenuated by p53 mutation or deletion. 29022915 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Association of TP53 codon 72 and CDH1 genetic polymorphisms with colorectal cancer risk in Bangladeshi population. 28554075 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Protein degradation rate is the dominant mechanism accounting for the differences in protein abundance of basal p53 in a human breast and colorectal cancer cell line. 28489927 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Antagonistic Effects of p53 and HIF1A on microRNA-34a Regulation of PPP1R11 and STAT3 and Hypoxia-induced Epithelial to Mesenchymal Transition in Colorectal Cancer Cells. 28435028 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE The incidence of RAS/RAF/PI3KA and TP53 gene mutations in colorectal cancer (CRC) is well established. 26797410 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Evidence demonstrate that p53 mutations and microRNAs (miRs) are important components of 5-FU resistance in colorectal cancer (CRC). miR-338-3p has been reported associated with cancer prognosis. 28928082 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE The prognostic value of p53 positive in colorectal cancer: A retrospective cohort study. 28468582 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE To test the association between common TP53 haplotypes and colorectal cancer (CRC) development. 28373458 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE This approach classified CRC into two major groups consistent with previous classification systems: (1) ∼16 % hypermutated cancers with either microsatellite instability (MSI) due to defective mismatch repair (∼13 %) or ultramutated cancers with DNA polymerase epsilon proofreading mutations (∼3 %); and (2) ∼84 % non-hypermutated, microsatellite stable (MSS) cancers with a high frequency of DNA somatic copy number alterations, which showed common mutations in APC, TP53, KRAS, SMAD4, and PIK3CA. 27325016 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) and P53 mutation pattern in sporadic colorectal cancer. 26314856 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE PRIMA-1met (APR-246) inhibits growth of colorectal cancer cells with different p53 status through distinct mechanisms. 26452133 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Tumor suppressor TP53 is frequently mutated in colorectal cancer (CRC), and most mutations are missense type. 28628120 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE KRAS and TP53 mutations in inflammatory bowel disease-associated colorectal cancer: a meta-analysis. 28077799 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE The tumor suppressor P53 is a critical regulator of normal cellular homeostasis whose function is either distorted or lost in several cancer types including colorectal cancer (CRC). 28656629 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE Colorectal cancer (CRC) is characterized by alteration of critical pathways such TP53 inactivation, BRAF, PI3CA mutations, APC inactivation, KRAS, TGF-β, CTNNB mutations, disregulation of Epithelial to mesnechymal transition (EMT) genes, WNT signaling activation, MYC amplification, and others. 28010901 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Differences in p53 status significantly influence the cellular response and cell survival to 1,25-dihydroxyvitamin D3-metformin cotreatment in colorectal cancer cells. 28618116 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE TP53 mutation at early stage of colorectal cancer progression from two types of laterally spreading tumors. 26991699 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 GeneticVariation disease BEFREE In this study a glycoproteomic approach was used to identify glycoproteins exhibiting alterations in glycosylation in colorectal cancer and to evaluate the changes in O-linked glycosylation in the context of the p53 and KRAS (codon 12/13) mutation status. 26495974 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE In vitro and in vivo assessments demonstrated aberrant induction of phosphorylated p53 at Serine 15 [phospho-p53(Ser15)] in human FBXW7-deficient CRC cells as compared to their FBXW7-wild-type counterparts. 25860929 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE ArhGAP30 promotes p53 acetylation and function in colorectal cancer. 25156493 2016
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.400 Biomarker disease BEFREE Our data suggest that ZFAS1 may function as oncogene in CRC by two main actions: (i) via destabilization of p53 and through (ii) interaction with CDK1/cyclin B1 complex leading to cell cycle progression and inhibition of apoptosis. 26506418 2016