Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3663
Gene Symbol: IRF5
IRF5 		0.140 GeneticVariation disease GWASCAT Genome-Wide Association Analysis Reveals Genetic Heterogeneity of Sjögren's Syndrome According to Ancestry. 28076899 2017
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.110 GeneticVariation disease GWASCAT Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. 24097067 2013
Entrez Id: 5649
Gene Symbol: RELN
RELN 		0.110 GeneticVariation disease GWASCAT Genome-Wide Association Analysis Reveals Genetic Heterogeneity of Sjögren's Syndrome According to Ancestry. 28076899 2017
Entrez Id: 5649
Gene Symbol: RELN
RELN 		0.110 GeneticVariation disease BEFREE In addition to confirming previously described SS susceptibility loci MSH5 (p = 1.67 × 10-5) and RELN (p = 4.91 × 10-6), we also validated PRAMEF13 (p = 2.28 × 10-5), TARBP1 (p = 1.87 × 10-5), UGT2B28 (p = 1.33 × 10-5), TRBV5-6 (p = 2.27 × 10-5) and NAPB (p = 3.73 × 10-5) as novel susceptibility loci for SS. 31349012 2019
Entrez Id: 640
Gene Symbol: BLK
BLK 		0.110 GeneticVariation disease BEFREE Genetic studies have identified associations of the FAM167A-BLK locus with rheumatoid arthritis, systemic lupus erythematosus (SLE) and Sjögren's syndrome. 29663334 2018
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1 		0.110 GeneticVariation disease BEFREE For instance, the DRB1*0301 haplotype involved in the genetic susceptibility to SS was more often associated with the DPB1* 0201 and TNF-a2 alleles in SS patients than in controls. 9844767 1999
Entrez Id: 3115
Gene Symbol: HLA-DPB1
HLA-DPB1 		0.110 GeneticVariation disease GWASCAT Genome-Wide Association Analysis Reveals Genetic Heterogeneity of Sjögren's Syndrome According to Ancestry. 28076899 2017
Entrez Id: 1822
Gene Symbol: ATN1
ATN1 		0.100 GeneticVariation disease BEFREE Our iPSC-MSCs inhibited the onset of lymphocyte infiltration into salivary glands in the NOD mouse model of SS in the same way as BM-MSCs. 29736173 2018
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.100 GeneticVariation disease BEFREE The IL-17 7488A/G variant showed correlation with presence of anti-SmB and anti-dsDNA antibodies, while the IL-17F 7383A/G variant was associated with Sjögren's syndrome and leuco-and thrombocytopenia. 25159155 2015
Entrez Id: 1822
Gene Symbol: ATN1
ATN1 		0.100 GeneticVariation disease BEFREE To determine whether development contributes to autoimmunity, we compared four target organs in NOD mice (an animal model for type 1 diabetes and Sjogren's syndrome) with NOD-SCID mice (which lack lymphocytes) and normal controls. 18301381 2008
Entrez Id: 6741
Gene Symbol: SSB
SSB 		0.100 GeneticVariation disease BEFREE Targeted deletion of the gene encoding the La autoantigen (Sjögren's syndrome antigen B) in B cells or the frontal brain causes extensive tissue loss. 24190965 2014
Entrez Id: 101928376
Gene Symbol: IL12A-AS1
IL12A-AS1 		0.100 GeneticVariation disease GWASCAT Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. 24097067 2013
Entrez Id: 10219
Gene Symbol: KLRG1
KLRG1 		0.100 GeneticVariation disease GWASCAT Genome-Wide Association Analysis Reveals Genetic Heterogeneity of Sjögren's Syndrome According to Ancestry. 28076899 2017
Entrez Id: 1822
Gene Symbol: ATN1
ATN1 		0.100 GeneticVariation disease BEFREE Our objective was to characterize local and systemic SS manifestations in depth in NOD.B10 female mice at early and late disease time points. 28526333 2017
Entrez Id: 394214
Gene Symbol: COL11A2P1
COL11A2P1 		0.100 GeneticVariation disease GWASDB A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23. 24097066 2013
Entrez Id: 1822
Gene Symbol: ATN1
ATN1 		0.100 GeneticVariation disease BEFREE We conclude that treatment with BD-MSCs increases tear production in the NOD mouse model of Sjögren's syndrome. 28348600 2017
Entrez Id: 811
Gene Symbol: CALR
CALR 		0.100 GeneticVariation disease BEFREE Our data demonstrated that the functional variant, rs10774671, is associated with HBV infection and anti-SSA antibody-positive SS. 29242559 2017
Entrez Id: 6737
Gene Symbol: TRIM21
TRIM21 		0.100 GeneticVariation disease BEFREE Our data demonstrated that the functional variant, rs10774671, is associated with HBV infection and anti-SSA antibody-positive SS. 29242559 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10 		0.100 GeneticVariation disease BEFREE SNP variations in IL10, TNFα and TNFAIP3 genes in patients with dry eye syndrome and Sjogren's syndrome. 30923465 2019
Entrez Id: 394214
Gene Symbol: COL11A2P1
COL11A2P1 		0.100 GeneticVariation disease GWASCAT A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23. 24097066 2013
Entrez Id: 1822
Gene Symbol: ATN1
ATN1 		0.100 GeneticVariation disease BEFREE We investigated the effect of blockade of the lymphotoxin-beta receptor (LTBR) pathway on lacrimal-gland pathology in the NOD mouse model of Sjögren's syndrome. 22044682 2011
Entrez Id: 3458
Gene Symbol: IFNG
IFNG 		0.100 GeneticVariation disease BEFREE To clarify the molecular mechanisms of Sjögren's syndrome (SS), we analyzed the functional role of the STAT-1 gene, one of the interferon-gamma (IFNgamma)-inducible genes, in labial salivary glands (LSGs) from SS patients. 17075845 2006
Entrez Id: 3605
Gene Symbol: IL17A
IL17A 		0.100 GeneticVariation disease BEFREE IL-17A (-197G/A) and IL-17F (7488T/C) polymorphisms are not associated with the susceptibility nor to the severity of RA and sSS in the studied population. 26232893 2016
Entrez Id: 729993
Gene Symbol: SHISA9
SHISA9 		0.100 GeneticVariation disease GWASCAT Genome-Wide Association Analysis Reveals Genetic Heterogeneity of Sjögren's Syndrome According to Ancestry. 28076899 2017
Entrez Id: 3122
Gene Symbol: HLA-DRA
HLA-DRA 		0.100 GeneticVariation disease GWASCAT Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. 24097067 2013