Gene: APOE ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human Using the Apolipoprotein E Knock-Out Mouse Model to Define Atherosclerotic Plaque Changes Induced by Low Dose Arsenic. 30376133 2018
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human Sinigrin attenuates the progression of atherosclerosis in ApoE-/- mice fed a high-cholesterol diet potentially by inhibiting VCAM-1 expression. 28483571 2017
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human Pulmonary exposure to particles from diesel exhaust, urban dust or single-walled carbon nanotubes and oxidatively damaged DNA and vascular function in apoE(-/-) mice. 23148895 2014
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human Chronic ingestion of H1-antihistamines increase progression of atherosclerosis in apolipoprotein E-/- mice. 25020133 2014
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human Diesel exhaust particulate increases the size and complexity of lesions in atherosclerotic mice. 24330719 2013
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human Dietary quercetin attenuates oxidant-induced endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet: a critical role for heme oxygenase-1. 24017971 2013
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human Cigarette smoke induces molecular responses in respiratory tissues of ApoE(-/-) mice that are progressively deactivated upon cessation. 24096154 2013
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human Inhibitory effects of myricitrin on oxidative stress-induced endothelial damage and early atherosclerosis in ApoE-/- mice. 23639522 2013
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human Inherent and benzo[a]pyrene-induced differential aryl hydrocarbon receptor signaling greatly affects life span, atherosclerosis, cardiac gene expression, and body and heart growth in mice. 22228805 2012
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human Exposure to moderate arsenic concentrations increases atherosclerosis in ApoE-/- mouse model. 21512104 2011
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human Kaempferol regulates OPN-CD44 pathway to inhibit the atherogenesis of apolipoprotein E deficient mice. 22005275 2011
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human Augmented atherogenesis in LDL receptor deficient mice lacking both macrophage ABCA1 and ApoE. 22022523 2011
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human Activation of TRPV1 reduces vascular lipid accumulation and attenuates atherosclerosis. 21908651 2011
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human Antiatherogenic effect of bisvanillyl-hydralazone, a new hydralazine derivative with antioxidant, carbonyl scavenger, and antiapoptotic properties. 21043830 2011
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E-knockout mice by alleviating inflammation and endothelial dysfunction. 20093625 2010
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human Arsenic exacerbates atherosclerotic lesion formation and inflammation in ApoE-/- mice. 19682479 2009
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human Thieno[2,3-c]isoquinolin-5-one, a potent poly(ADP-ribose) polymerase inhibitor, promotes atherosclerotic plaque regression in high-fat diet-fed apolipoprotein E-deficient mice: effects on inflammatory markers and lipid content. 19124646 2009
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death. 17438151 2007
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human [Rosiglitazone enhances the anti-atherosclerotic effects of peroxisome proliferator-activated receptor gamma1 gene transfer in apolipoprotein-knock out mice]. 18269830 2007
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human 12/15-Lipoxygenase gene disruption and vitamin E administration diminish atherosclerosis and oxidative stress in apolipoprotein E deficient mice through a final common pathway. 16303615 2005
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human Rosiglitazone attenuates atherosclerosis in a model of insulin insufficiency independent of its metabolic effects. 16020748 2005
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human Superoxide dismutase mimetic M40403 improves endothelial function in apolipoprotein(E)-deficient mice. 12871831 2003
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human Arsenic exposure accelerates atherogenesis in apolipoprotein E(-/-) mice. 14594625 2003
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human Anti-atherosclerotic effect of simvastatin depends on the presence of apolipoprotein E. 11947894 2002
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.300 Biomarker phenotype CTD_human Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: pleiotropic effects on CD36 expression and HDL. 11231916 2001