This study evaluated the association between urinary cadmium (U-Cd) and blood Cd (B-Cd) and several biomarkers of renal dysfunction (α<sub>1</sub> -microglobulin [α<sub>1</sub> -MG], β<sub>2</sub> -microglobulin [β<sub>2</sub> -MG], N-acetyl-β-d-glucosaminidase, metallothionein, retinol-binding protein and microalbumin [mALB]) and identified the biomarker(s) that was most closely correlated with U-Cd and B-Cd among female residents in rural areas of southwest China.
Before and after the first course of chemotherapy, we measured urinary A- and C-megalin and other markers of PTEC injury, such as N-acetyl-β-D-glucosaminidase, α<sub>1</sub>-microglobulin, β<sub>2</sub>-microglobulin, neutrophil gelatinase-associated lipocalin, and liver-type fatty acid-binding protein, and compared the values with the change in the estimated glomerular filtration rate (eGFR) and clinical risk factors for renal impairment.