Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE
0.440 Biomarker disease BEFREE Serum Amyloid A Stimulates Vascular and Renal Dysfunction in Apolipoprotein E-Deficient Mice Fed a Normal Chow Diet. 30899260 2019
Entrez Id: 348
Gene Symbol: APOE
APOE
0.440 Biomarker disease BEFREE On the other hand, the administration of fibrate with the intensive control of triglyceride and apolipoprotein E particularly from the early phase will ameliorate LPG and prevent renal dysfunction. 24149835 2014
Entrez Id: 348
Gene Symbol: APOE
APOE
0.440 Biomarker disease CTD_human Successful treatment of lipoprotein glomerulopathy in a daughter and a mother using niceritrol. 20842518 2010
Entrez Id: 348
Gene Symbol: APOE
APOE
0.440 GeneticVariation disease BEFREE The APOE epsilon2 allele does not seem to be associated with increased risk of renal impairment in Chinese type 2 diabetic patients. 18774543 2008
Entrez Id: 348
Gene Symbol: APOE
APOE
0.440 GeneticVariation disease BEFREE Lipid and lipoprotein parameters, including levels of total, HDL, and LDL cholesterol; triglycerides; lipoprotein(a); apolipoprotein A-IV; and the apolipoprotein E and A-IV polymorphisms, were assessed in 177 patients who had mostly mild to moderate renal insufficiency and were followed prospectively for up to 7 yr. 16382017 2006
Entrez Id: 348
Gene Symbol: APOE
APOE
0.440 Biomarker disease HPO
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.420 Biomarker disease BEFREE TLR4 deficiency ameliorated renal dysfunction (serum BUN and creatinine) and tubular endothelial apoptosis determined by immunofluorescence staining of CD31 and TUNEL, and western blot of apoptotic protein (caspase-3, c-caspase-3, and Bax/Bcl-2 ratio). 30099700 2019
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.420 Biomarker disease CTD_human TLR4-mediated inflammation is a key pathogenic event leading to kidney damage and fibrosis in cyclosporine nephrotoxicity. 27585667 2017
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.420 Biomarker disease BEFREE The purpose of this review is to describe the basis for how ligand binding to TLR4 has the potential to cause renal dysfunction and the mechanisms by which this may take place in gram-negative sepsis. 27602552 2017
Entrez Id: 2717
Gene Symbol: GLA
GLA
0.420 AlteredExpression disease BEFREE Fabry disease results from deficient α-galactosidase A activity and globotriaosylceramide accumulation causing renal insufficiency, strokes, hypertrophic cardiomyopathy and early demise. 25795794 2015
Entrez Id: 2717
Gene Symbol: GLA
GLA
0.420 Biomarker disease GENOMICS_ENGLAND Results of a nationwide screening for Anderson-Fabry disease among dialysis patients. 15100373 2004
Entrez Id: 2717
Gene Symbol: GLA
GLA
0.420 GeneticVariation disease BEFREE This cardiac variant serves as an "experiment of nature" showing that the residual alpha-Gal A activity precludes glycosphingolipid deposition in the renal endothelial and other cells that lead to early renal failure in classically affected men, whereas marked podocyte accumulation is associated with proteinuria and possibly late-onset renal dysfunction. 14712441 2004
Entrez Id: 2717
Gene Symbol: GLA
GLA
0.420 Biomarker disease HPO
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.420 Biomarker disease HPO
Entrez Id: 183
Gene Symbol: AGT
AGT
0.400 AlteredExpression disease BEFREE We observe a positive correlation between miR-103a-3p levels and AngII-induced renal dysfunction. miR-103a-3p suppresses expression of the sucrose non-fermentable-related serine/threonine-protein kinase SNRK in glomerular endothelial cells, and glomeruli of HN patients and AngII-infused mice show reduced endothelial expression of SNRK. 31086184 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.400 Biomarker disease BEFREE We excluded patients who had taken steroids or ACE inhibitors and patients with renal impairment. 31300268 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.400 AlteredExpression disease BEFREE A number of vasoactive mediators including proprotein convertase subtilisin-kexin type 9 (PCSK9), endothelin-1, nitric oxide, and angiotensin II have fundamental roles in the pathophysiology of atherosclerotic events; moreover, their levels are affected by dyslipidemia and oxidative stress due to renal dysfunction. 31641998 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.400 Biomarker disease BEFREE We evaluated the hypothesis that the development of renal dysfunction and congestive heart failure (CHF) caused by volume overload in rats with angiotensin II (ANG II)-dependent hypertension is associated with altered renal vascular responsiveness to ANG II and to epoxyeicosatrienoic acids (EETs). 31430751 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.400 GeneticVariation disease BEFREE Possibly, the development of renal dysfunction in the females, unlike in males, is associated with altered renal vascular responsiveness to angiotensin II (ANG II). 31505499 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.400 Biomarker disease BEFREE Results show that SGK1 inhibitor EMD638683 significantly reversed renal dysfunction and cardiac dysfunction in echocardiography as indicated by decreased blood urine nitrogen and serum creatinine in AngII-infused mice. 30524295 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.400 Biomarker disease BEFREE Effect of angiotensin-converting enzyme blockade, alone or combined with blockade of soluble epoxide hydrolase, on the course of congestive heart failure and occurrence of renal dysfunction in Ren-2 transgenic hypertensive rats with aorto-caval fistula. 29527914 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.400 Biomarker disease BEFREE The most common potential omissions at the admission were beta-blockers in cases of stable chronic angina, and angiotensin converting enzyme inhibitors or angiotensin receptor blockers in cases of diabetic nephropathy or renal dysfunction. 30242588 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.400 GeneticVariation disease BEFREE Therapeutic drug monitoring of angiotensin-converting enzyme inhibitors has a great impact on blood pressure control in patients with heart failure and hepatic and renal impairment. 30109716 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.400 Biomarker disease BEFREE This study evaluated the potential effect of hydration intensity on the role of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) on contrast-induced nephropathy in patients with renal insufficiency. 28490226 2018
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.400 Biomarker disease CTD_human Nephropathy in Pparg-null mice highlights PPARγ systemic activities in metabolism and in the immune system. 28182703 2017