Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE
0.440 Biomarker disease BEFREE On the other hand, the administration of fibrate with the intensive control of triglyceride and apolipoprotein E particularly from the early phase will ameliorate LPG and prevent renal dysfunction. 24149835 2014
Entrez Id: 348
Gene Symbol: APOE
APOE
0.440 Biomarker disease CTD_human Successful treatment of lipoprotein glomerulopathy in a daughter and a mother using niceritrol. 20842518 2011
Entrez Id: 348
Gene Symbol: APOE
APOE
0.440 Biomarker disease BEFREE The reduction of circulating sFlt-1 and renal sFlt-1 mRNA levels was confirmed in five-sixths (5/6)-nephrectomized apolipoprotein E-deficient mice that developed experimental renal dysfunction. 19948974 2010
Entrez Id: 348
Gene Symbol: APOE
APOE
0.440 GeneticVariation disease BEFREE The APOE epsilon2 allele does not seem to be associated with increased risk of renal impairment in Chinese type 2 diabetic patients. 18774543 2009
Entrez Id: 348
Gene Symbol: APOE
APOE
0.440 GeneticVariation disease BEFREE Lipid and lipoprotein parameters, including levels of total, HDL, and LDL cholesterol; triglycerides; lipoprotein(a); apolipoprotein A-IV; and the apolipoprotein E and A-IV polymorphisms, were assessed in 177 patients who had mostly mild to moderate renal insufficiency and were followed prospectively for up to 7 yr. 16382017 2006
Entrez Id: 348
Gene Symbol: APOE
APOE
0.440 Biomarker disease HPO
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.390 GeneticVariation disease BEFREE However, ACE gene I/D polymorphisms were associated with the severe proteinuria and renal dysfunction seen in preeclampsia. 17710578 2007
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.390 GeneticVariation disease BEFREE There was no significant relationship detected between the D allele of ACE, the C allele of AT1R or the T allele of AGT genes and response to steroid therapy, extent of renal dysfunction and the progression to ESRD. 16525944 2006
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.390 Biomarker disease BEFREE The associations AGT TT-AT1R AC and CYP11B2 CC-ACE DD showed a possible positive interaction in the development of renal insufficiency among hypertensive subjects. 15662219 2005
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.390 GeneticVariation disease BEFREE These findings suggest an interaction between ACE and ADD1 polymorphisms not only on blood pressure regulation but also on the progression of renal dysfunction in patients with IgAN. 12885793 2004
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.390 GeneticVariation disease BEFREE There were no significant differences between the distribution of ACE gene genotypes and lupus nephritis and its related parameters, including WHO classification, activity index, chronicity index, renal dysfunction and amount of 24 h urinary protein. 12043886 2003
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.390 Biomarker disease BEFREE Most angiotensin-converting enzyme (ACE) inhibitors and their metabolites are excreted renally and doses should hence be reduced in renal insufficiency. 11881130 2002
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.390 GeneticVariation disease BEFREE In this phenotypically more homogeneous subgroup, serum creatinine level was 3.6 micromol/L (P = 0.02) and relative risks for mild renal dysfunction and proteinuria were 1.7-fold (P < 0.001) and 26% (P = 0.02) greater in ACE D subjects than ACE II homozygotes, respectively. 11728946 2001
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.390 GeneticVariation disease BEFREE The results in this study in non-diabetic patients with chronic renal disease indicate that the presence of the D allele in the ACE genotype may be of particular importance as a predictor of a high rate of progression in male patients who otherwise do not have a major burden of documented and important prognostic factors for progressive renal insufficiency. 10727542 2000
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.390 GeneticVariation disease BEFREE We observed a significant association of the deletion polymorphism of ACE gene with renal insufficiency, hypertension and severe glomerular lesions at biopsy. 9594210 1998
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.390 Biomarker disease CTD_human Association of angiotensinogen gene T235 variant with progression of immunoglobin A nephropathy in Caucasian patients. 9259580 1997
Entrez Id: 183
Gene Symbol: AGT
AGT
0.380 AlteredExpression disease BEFREE Moreover, the augmented intrarenal AGT mRNA expression paralleled renal dysfunction in patients with diabetes. 24284398 2014
Entrez Id: 183
Gene Symbol: AGT
AGT
0.380 Biomarker disease BEFREE We examined the hypothesis that vascular and renal dysfunction caused by angiotensin II (Ang II) through increased levels of blood pressure, inflammatory cytokines, and oxidative stress in Sprague-Dawley rats can be prevented by lentiviral-mediated delivery of endothelial heme oxygenase (HO)-1. 20836698 2011
Entrez Id: 183
Gene Symbol: AGT
AGT
0.380 GeneticVariation disease BEFREE Renin-angiotensin-aldosterone system (RAAS) polymorphisms such as the angiotensinogen-gene-M235T-, the angiotensin-conversion enzyme (ACE)-gene I/D- and the angiotensin-II-type 1-receptor-(AT1R)-A1166C-polymorphism have been implicated in renal insufficiency and hypertension. 19681973 2010
Entrez Id: 183
Gene Symbol: AGT
AGT
0.380 Biomarker disease BEFREE Genetic polymorphisms of angiotensin-2 type 1 receptor and angiotensinogen and risk of renal dysfunction and coronary heart disease in type 2 diabetes mellitus. 19327134 2009
Entrez Id: 183
Gene Symbol: AGT
AGT
0.380 GeneticVariation disease BEFREE In this study, the angiotensinogen -235T allele was found to be related with steroid resistance, renal dysfunction and progression of ESRD in nephrotic syndrome. 16525944 2006
Entrez Id: 183
Gene Symbol: AGT
AGT
0.380 Biomarker disease BEFREE A prospective population-based study of CKD risk was conducted among 3706 black individuals without severe renal dysfunction at baseline (serum creatinine > or =177 micromol/L [2.0 mg/dl] for men, > or =159 micromol/L [1.8 mg/dl] for women) to examine associations with AGT and AT1R. 16396964 2006
Entrez Id: 183
Gene Symbol: AGT
AGT
0.380 Biomarker disease BEFREE The associations AGT TT-AT1R AC and CYP11B2 CC-ACE DD showed a possible positive interaction in the development of renal insufficiency among hypertensive subjects. 15662219 2005
Entrez Id: 183
Gene Symbol: AGT
AGT
0.380 GeneticVariation disease BEFREE Recently it was reported that polymorphism at -20 from adenine to cytosine in the angiotensinogen gene, increasing the level of this transcript, was associated with the progression of renal dysfunction in adult IgA nephropathy. 14648325 2004
Entrez Id: 183
Gene Symbol: AGT
AGT
0.380 Biomarker disease CTD_human Association of angiotensinogen gene T235 variant with progression of immunoglobin A nephropathy in Caucasian patients. 9259580 1997